Product Details
| Product Name:
NST-628 |
CAS No.:
3002056-30-3 |
| Purity:
98.62% |
Supply Ability:
10g |
| Release date:
2025/08/30 |
Product Introduction
Bioactivity
| Name | NST-628 |
| Description | NST-628 is a pan-RAF-MEK molecular glue that prevents RAF from phosphorylating and activating MEK, inhibiting the RAF-MEK signaling complex. |
| In vitro | NST-628 demonstrates elevated antiproliferative activity in BRAF Class II/III mutant cell models compared to other RAF and MEK inhibitors, without promoting heterodimer formation of BRAF and CRAF. [1]
NST-628 (4-100 nM; 48 h) induces early and late apoptosis in a dose-dependent manner and decreases live cell populations in NRAS mutant IPC-298 and SK-MEL-2, NF1 mutant MeWo, and KRAS mutant HCT116 cell lines. [1] |
| In vivo | NST-628 when administered orally (p.o.) at doses of 3 mg/kg and 5 mg/kg once daily (qd), or 1.5 mg/kg twice daily (b.i.d), significantly slowed tumor growth in models with KRAS and NRAS mutations. In the SK-MEL-2-luc model, it caused tumor regression. [1]
Administered intragastrically (i.g.) at 0.3-3 mg/kg once daily for 18-20 days, NST-628 inhibited the RAS-MAPK pathway in mice in a dose-dependent manner, showing strong anti-tumor activity in the MeWo-luc model. At a dose of 2 mg/kg once daily for 26 days in an NCI-H23 KRASG12C-mutant lung adenocarcinoma model, NST-628 effectively slowed tumor growth and significantly inhibited the RAS-MAPK pathway. [1] |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 80 mg/mL(163.78 mM), Sonication is recommended.
|
| Keywords | Raf | MEK |
| Inhibitors Related | Regorafenib monohydrate | Exarafenib | Doramapimod | Lidocaine | Sorafenib | Lidocaine hydrochloride | Regorafenib | Dabrafenib | Sorafenib tosylate | Honokiol | Trametinib | GW 441756 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
-
-
CAS:2098850-81-6
$199.00 / 1mg
-
CAS:512-64-1
$427.00 / 1mg
Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$1980.00/50mg |
VIP2Y
|
TargetMol Chemicals Inc.
|
2025-08-21 |
|
|
$0.00/1KG |
VIP4Y
|
Henan Aochuang Chemical Co.,Ltd.
|
2022-10-13 |
United States