OAB-14 NEW
| Price | $985 | $1280 | $1940 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-10-27 |
Product Details
| Product Name: OAB-14 | CAS No.: 2140911-49-3 |
| Supply Ability: 10g | Release date: 2025/10/27 |
Product Introduction
Bioactivity
| Name | OAB-14 |
| Description | OAB-14 is a Bexarotene derivative that improves Alzheimer's disease-related pathologies and cognitive impairments by increasing β-amyloid clearance in APP/PS1 mice. OAB-14 effectively ameliorates the dysfunction of the endosomal-autophagic-lysosomal(EAL) pathway in APP/PS1 transgenic mice [1] [2]. |
| In vivo | OAB-14 significantly improves cognitive function in amyloid precursor protein (APP)/presenilin 1 (PS1) transgenic mice when administered for either 15 days or 3 months, by promoting microglia phagocytosis, enhancing IDE and NEP levels, and reducing Aβ by 71%. This compound mitigates Aβ-induced pathological outcomes, including synaptic degeneration, neuronal loss, tau hyperphosphorylation, and neuroinflammation, without adversely affecting body weight or causing liver toxicity, even after prolonged use. Furthermore, OAB-14 boosts receptor-mediated endocytosis and normalizes autophagy flux through the AMPK/mTOR pathway, increasing lysosomal activity and decreasing Aβ accumulation in lysosomes of treated AD mice. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | OAB-14 |
| Inhibitors Related | BSBM7 | Notoginsenoside R1 | Geniposide | Thioflavin T | Deferoxamine Mesylate | Tramiprosate | HEPPS | Dihydroergocristine mesylate | Rutin | Direct Blue 1 | Methyl tridecanoate | Glimepiride |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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