PARG-IN-4 NEW
| Price | $215 | $538 | $868 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-06-26 |
Product Details
| Product Name: PARG-IN-4 | CAS No.: 2988890-20-4 |
| Purity: 98.51% | Supply Ability: 10g |
| Release date: 2025/06/26 |
Product Introduction
Bioactivity
| Name | PARG-IN-4 |
| Description | PARG-IN-4 (compound A) is an orally active and cell-membrane permeable PARG inhibitor (EC50=1.9 nM) that inhibits tumour growth in mice with antitumour activity. |
| In vitro | PARG-IN-4 shows strong anti-proliferative effects against ovarian and breast cancer cells. It inhibited cell growth with IC₅₀ values ranging from 8 nM (RMUG-S) to 0.37 μM (HCC1954), depending on the cell line[1]. |
| In vivo | In a patient-derived xenograft (PDX) mouse model (HBCx-34), oral administration of PARG-IN-4 (100 mg/kg, once daily for 45 days) led to complete tumor regression, achieving a tumor growth inhibition rate (TGI) of 110%[1]. |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 16 mg/mL (32.15 mM), Sonication is recommended. |
| Inhibitors Related | Stavudine | 5-Fluorouracil | Flubendazole | Cysteamine hydrochloride | L-Glutamic acid monosodium salt monohydrate | Myricetin | Sodium 4-phenylbutyrate | L-Ascorbic acid | L-Glutamic acid | Tributyrin | L-Ascorbic acid sodium salt | Alginic acid |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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