Product Details
| Product Name:
PB2 |
CAS No.:
914940-24-2 |
| Supply Ability:
10g |
Release date:
2026/04/22 |
Product Introduction
Bioactivity
| Name | PB2 |
| Description | PB2, a tris(2-carboxyethyl)phosphine (TCEP) analogue, enhances the survival of retinal ganglion cells (RGCs) following axotomy in vitro. Even at nanomolar and picomolar concentrations, PB2 demonstrates pronounced efficacy in promoting RGC survival. Notably, PB2 exhibits superior permeability compared to TCEP. Serving as a potent reducing agent, PB2 provides robust neuroprotection for RGCs[1]. |
| In vitro | PB2 (0.001~100000 nM; 72 hours; RGCs) increases RGC viability[1]. PB2's modifications neutralize compound polarity, and its methyl esters are likely cleaved by cytosolic esterases, producing a polar intracellular intermediate that is unlikely to cross cell membranes[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween-80+45% Saline : 3.3 mg/mL (11.53 mM), Sonication is recommended.
DMSO : 100 mg/mL (349.5 mM), Sonication is recommended.
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| Keywords | PB-2 | PB2 | PB 2 |
| Inhibitors Related | Rifampicin | Acetylcysteine | α-Vitamin E | Molnupiravir | Nitazoxanide | Curcumin | Baicalein | Naringenin | Salcomine | Benzimidazole | Dihydromyricetin | β-Cyclodextrin |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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