PI3Kα-IN-4 NEW
| Price | $1400 | $1820 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-10-27 |
Product Details
| Product Name: PI3Kα-IN-4 | CAS No.: 2322293-83-2 |
| Supply Ability: 10g | Release date: 2025/10/27 |
Product Introduction
Bioactivity
| Name | PI3Kα-IN-4 |
| Description | PI3Kα-IN-4 is a potent, selective, and orally active PI3Kα inhibitor with an IC50 of 1.8 nM, demonstrating antitumor activity [1]. |
| In vitro | PI3Kα-IN-4 (compound 10) inhibits PI3Kα, β, δ, and γ in kinase assays with IC50s of 1.8, 271.0, 13.9, and 13.8 nM, respectively, and in cell-based assays with IC50s of 12.1, 1393, 183, and >10000 nM, respectively [1]. |
| In vivo | PI3Kα-IN-4 (compound 10) (30 mg/kg; p.o. once daily for 21 days) achieves 73.0% tumor growth inhibition in mice. It dose-dependently suppresses tumor growth by 62.5% (15 mg/kg), 86.0% (30 mg/kg), and 90.7% (40 mg/kg) when administered orally once daily for 30 days. Time- and dose-dependent inhibition of Akt phosphorylation is observed in vivo (15-40 mg/kg; p.o. once daily; 1-4 h). The compound shows high Cmax (mouse 22167, rat 2327 nM) and good bioavailability (mouse 59.4%, rat 46.9%) after oral administration (mouse 10, rat 3 mg/kg). Following intravenous injection (mouse 1, rat 1 mg/kg), it has a t1/2 of 0.99 hours in mice and 1.22 hours in rats, with low plasma clearance (mouse 4.16, rat 5.28 mL/min/kg). |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 100 mg/mL (178.57 mM), Sonication is recommended. |
| Keywords | PI-3Kα-IN-4 | PI3Ka-IN-4 | PI3Kalpha-IN-4 | PI3Kα IN 4 | PI3KαIN4 |
| Inhibitors Related | Musk ketone | Myricetin | Erucic acid | 4-Methylbenzylidene camphor | (±)-α-Bisabolol | Berberine hydrogen sulphate | Isoprenaline hydrochloride | Thymoquinone | Quercetin | Inavolisib | Berberine sulfate | Apilimod |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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