PKI-179 NEW
| Price | $767 | $997 | $1610 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-10-27 |
Product Details
| Product Name: PKI-179 | CAS No.: 1197160-28-3 |
| Supply Ability: 10g | Release date: 2025/10/27 |
Product Introduction
Bioactivity
| Name | PKI-179 |
| Description | PKI-179 is a potent, orally active compound that functions as a dual PI3K/mTOR inhibitor. It demonstrates IC50 values of 8 nM for PI3K-α, 24 nM for PI3K-β, 74 nM for PI3K-γ, 77 nM for PI3K-δ, and 0.42 nM for mTOR. Additionally, it is effective against E545K and H1047R mutations, with IC50s of 14 nM and 11 nM, respectively. In vivo studies have shown that PKI-179 possesses anti-tumor capabilities[1][2]. |
| In vitro | PKI-179 inhibits cell proliferation with IC50s of 22 nM and 29 nM for MDA361 and PC3 cells, respectively[1]. It shows inhibitory activity against a panel of 361 other kinases, hERG, and cytochrome P450 (CYP) isoforms at concentrations up to >30 μM, but remains active for CYP2C8 (IC50=3 μM)[1]. |
| In vivo | PKI-179 (5-50 mg/kg; p.o. once daily for 40 days) inhibits tumor growth and is well tolerated in nude mice bearing MDA-361 human breast cancer tumors. PKI-179 (50 mg/kg; p.o.) effectively inhibits PI3K signaling in nude mice with MDA361 tumor xenografts. PKI-179 demonstrates good oral bioavailability (98% in nude mouse, 46% in rat, 38% in monkey, and 61% in dog) and a high half-life (>60 min) [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | PKI179 | PKI 179 | PKI-179 |
| Inhibitors Related | Musk ketone | Myricetin | Erucic acid | 4-Methylbenzylidene camphor | (±)-α-Bisabolol | Berberine hydrogen sulphate | Isoprenaline hydrochloride | Thymoquinone | Quercetin | Dihydromyricetin | Berberine sulfate | Apilimod |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
You may like
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $2100.00/25kg |
VIP6Y
|
Gansu Jinyuantai New Material Co., Ltd.
|
2023-12-27 | |
| $838.00/10mg |
VIP6Y
|
TargetMol Chemicals Inc.
|
2025-08-21 | |
| $500.00/100MG |
Hubei Chuchang Biotech Co., Ltd.
|
2024-06-03 |
United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
INQUIRY