Pozanicline dihydrochloride NEW
| Price | $79 |
| Package | 2mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-09-18 |
Product Details
| Product Name: Pozanicline dihydrochloride | CAS No.: 161416-61-1 |
| Supply Ability: 10g | Release date: 2025/09/18 |
Product Introduction
Bioactivity
| Name | Pozanicline dihydrochloride |
| Description | Pozanicline dihydrochloride (ABT-089 dihydrochloride) is an orally bioavailable agonist of the nicotinic acetylcholine receptor (nAChR) with a Ki of 16.7 nM. |
| In vitro | Pozanicline is a partial agonist at α4β2 nAChR. Moreover, one α6β2 nAChR subtype is particularly sensitive to Pozanicline (EC50 of 0.11 μM)[2]. Pozanicline shows high selectivity for α6β2 and α4α5β2 nAChR subtypes[3]. |
| In vivo | ABT-089, a partial agonist of α4β2*, and ABT-107, an α7 nicotinic acetylcholine receptor agonist, for amelioration of cognitive deficits induced by withdrawal from chronic nicotine in mice.?Mice underwent chronic nicotine administration (12.6 mg/kg/day or saline for 12 days), followed by 24 h of withdrawal.?At the end of withdrawal, mice received 0.3 or 0.6 mg/kg ABT-089 or 0.3 mg/kg ABT-107 (doses were determined through initial dose-response experiments and prior studies) and were trained and tested for CFC.?Nicotine withdrawal produced deficits in CFC that were reversed by acute ABT-089, but not ABT-107.?Cued conditioning was not affected.?modulation of hippocampal learning and memory using ABT-089 may be an effective component of novel therapeutic strategies for nicotine addiction[3]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : 100 mg/mL (377.1 mM), Sonication is recommended. |
| Keywords | α4β2 nAChR | receptor | Pozanicline Dihydrochloride | Pozanicline dihydrochloride | Pozanicline | Parkinson | Nicotinic acetylcholine receptors | nicotinic | nAChR | Inhibitor | inhibit | dopamine | disease | Alzheimer | acetylcholine | ABT-089 Dihydrochloride | ABT089 Dihydrochloride | ABT-089 | ABT089 | ABT 089 Dihydrochloride | ABT 089 |
| Inhibitors Related | Adiphenine hydrochloride | Nanofin | Forskolin | Pilocarpine Hydrochloride | (+)-Sparteine | Clozapine N-Oxide | Pilocarpine nitrate | Ribavirin | D-Menthol | Amitriptyline hydrochloride | Choline chloride | Propoxur |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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