Propargyl-PEG3-alcohol NEW

PRODUCT INFORMA

• Properties

• Spectrum

 Names

Name	2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethanol
Synonym	More Synonyms

 Propargyl-PEG3-alcohol Biological Activity

Description	Propargyl-PEG3-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References	[1]. Andrew P. Crew, et al. Brm targeting compounds and associated methods of use. US20190300521A1.

 Chemical & Physical Properties

Molecular Formula	C9H16O4
Molecular Weight	188.22100
Exact Mass	188.10500
PSA	47.92000

 Synthetic Route

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3-Bromopropyne CAS#:106-96-7 Triethylene glycol CAS#:112-27-6 ~73% Propargyl-PEG3-... CAS#:208827-90-1

Literature: Wang, Tao; Ng, David Y. W.; Wu, Yuzhou; Thomas, Jessica; Tamtran, Thuy; Weil, Tanja Chemical Communications, 2014 , vol. 50, # 9 p. 1116 - 1118

Tos-PEG3 CAS#:77544-68-4 Propargyl alcohol CAS#:107-19-7 ~44% Propargyl-PEG3-... CAS#:208827-90-1

Literature: Baccaro, Anna; Weisbrod, Samuel H.; Marx, Andreas Synthesis, 2007 , # 13 p. 1949 - 1954

3-Bromopropyne CAS#:106-96-7 Triethylene glycol CAS#:112-27-6 ~30% Bis-propargyl-PEG3 CAS#:126422-58-0 Propargyl-PEG3-... CAS#:208827-90-1

Literature: Gavrilyuk, Julia I.; Wuellner, Ulrich; Barbas III, Carlos F. Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 5 p. 1421 - 1424

 Precursor & DownStream

Precursor  4
CAS#:106-96-7 3-Bromopropyne  CAS#:112-27-6 Triethylene glycol  CAS#:77544-68-4 Tos-PEG3  CAS#:107-19-7 Propargyl alcohol
DownStream  0

 Synonyms

1-O-propargyl triethylene glycol

Company Profile

Our company is a high-tech enterprise specializing in chemical raw materials such as electronic materials, optoelectronic materials, semiconductor materials, UV monomers, silane catalysts, cosmetic raw materials, etc. The company integrates research and development, production, customized synthesis, and sales, and is committed to providing customers with high-quality chemical product solutions.

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