Product Details
| Product Name:
Quinoprazine |
CAS No.:
115618-99-0 |
| Supply Ability:
10g |
Release date:
2025/10/27 |
Product Introduction
Bioactivity
| Name | Quinoprazine |
| Description | Quinoprazine, a powerful inhibitor of Vaccinia virus DNA synthesis (IC50 = 10 μM), exhibits notable antimalarial activity against Plasmodium berghei. Additionally, it demonstrates significant antiprion potency, effectively reducing levels of PrPSc [1]-[5]. |
| In vitro | Quinoprazine exhibits antimalarial properties against the chloroquine-resistant Plasmodium berghei strain, LN-K65 [1], and impedes Vaccinia Virus infection by obstructing DNA synthesis [2]. As IND2118, it demonstrates significant antiprion efficacy by reducing PrP Sc levels by 76% in dividing cells and 51% in nondividing cells, with reductions over 30% regarded as potent [3] [4]. Moreover, IND2118 has low cytotoxicity, diminishing cell viability by only 25% in dividing cells and 24% in nondividing cells, with reductions below 30% considered safe [3] [4]. |
| In vivo | Quinoprazine, a 1-alkyl-4-[4-(heterylamino)phenyl]piperazine derivative, effectively suppresses Echinococcus multilocularis larvocyst growth in cotton rats at a dosage of 0.25 g/kg intraperitoneally (i.p.) in a single dose. Furthermore, at oral (p.o.) dosages ranging from 0.2 to 0.5 g/kg, it radically eradicates adult Hymenolepis nana infections in mice, as demonstrated in experimental studies [5]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Inhibitors Related | Picaridin | Flubendazole | Kojic acid | Urethane | Hydroxychloroquine | Metronidazole | Nitazoxanide | 2-Amino-2-methyl-1-propanol | Doxycycline | Fenpyroximate | Coumaran | Cloxiquine |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States