R-PSOP NEW
| Price | $1400 | $1820 | $2820 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-07-16 |
Product Details
| Product Name: R-PSOP | CAS No.: 1185189-97-2 |
| Supply Ability: 10g | Release date: 2025/07/16 |
Product Introduction
Bioactivity
| Name | R-PSOP |
| Description | R-PSOP is a potent and selective nonpeptidic NMUR2 antagonist, exhibiting binding affinity to human and rat NMUR2 with Ki values of 52 nM and 32 nM, respectively. This compound demonstrates moderate central nervous system (CNS) penetration and is valuable in the study of eating disorders, obesity, pain, and stress-related disorders [1]. |
| In vitro | According to Schild analyses, R-PSOP exhibits functional K_b values of 92 nM for human NMUR2 and 155 nM for rat NMUR2, highlighting its inhibitory effect on intracellular calcium mobilization triggered by NMU-25 in HEK293 cells expressing NMUR2 (the effects of R-PSOP on intracellular calcium mobilization induced by NMU-25 in HEK293 cells expressing human or rat NMUR2) [1]. Furthermore, R-PSOP effectively suppresses the activity initiated by peptide agonists NMU-25, NMU-23, and NMU-8 in these cells. The compound also concentration-dependently diminishes phosphoinositide (PI) turnover stimulated by 10 nM NMU-25 in cells expressing human NMUR2, showing an EC_50 of 5 nM and an IC_50 value of 86 nM [1]. These findings underscore R-PSOP's potent inhibitory effects on specific biochemical responses in human embryonic kidney 293 cells expressing NMUR2. |
| In vivo | R-PSOP (10 μL, 50 nmol; intrathecal injection; male Sprague-Dawley rats) reduces nociceptive responses induced by NMU-23 in a spinal reflex setup, indicating its analgesic potential [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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