Product Details
| Product Name:
RMC-5552 |
CAS No.:
2382768-62-7 |
| Supply Ability:
10g |
Release date:
2025/09/29 |
Product Introduction
Bioactivity
| Name | RMC-5552 |
| Description | RMC-5552 is a potent and selective inhibitor of mTORC1 that blocks phosphorylation of downstream signaling targets pS6K and p4EBP1 with IC50 values of 0.14 nM and 0.48 nM, respectively. RMC-5552 shows markedly reduced inhibition of pAKT (IC50 19 nM), achieving approximately 40-fold selectivity for mTORC1 over mTORC2. RMC-5552 has demonstrated anticancer activity, supporting its potential use as a therapeutic agent in oncology and as a research tool for dissecting mTOR signaling pathways. |
| In vitro | The recruitment phenomenon of FKBP12 can only be detected when RMC-5552 exerts its effect through the FKBP12-FRB binding mode of broussonetia papyrifera. RMC-5552 exhibits distinct density distribution at the interaction interface region between FKBP12 and the mTOR FRB domain of broussonetia papyrifera. The 4-aminopyrazolo[3,4-d]pyrimidine core of RMC-5552 achieves binding by forming hydrogen bonds with the backbone residues G2238 and V2240 in the 'hinge region' of the mTOR protein, while the 2-aminobenzoxazole group of RMC-5552 establishes hydrogen bond interactions with sites E2190 and K2187.[1] |
| In vivo | RMC-5552 (1-10 mg/kg, administered once weekly for 28 consecutive days) was intraperitoneally injected into MCF-7 breast cancer Homo sapiens xenograft model mice, demonstrating antitumor activity in vivo. [1] |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : ≥ 80 mg/mL, Sonication is recommended.
|
| Keywords | RMC 5552 |
| Inhibitors Related | α-Hydroxyglutaric Acid Lithium | L-Leucine | Sapanisertib | Bicyclol | Bimiralisib | Cbz-B3A | Aloe emodin | GDC0084 | TMBIM6 antagonist-1 | P-2281 | Dihydromyricetin | Rapamycin |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States