S-methyl DM1 NEW
| Price | $1670 | $2180 | $2800 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-10-27 |
Product Details
| Product Name: S-methyl DM1 | CAS No.: 912569-84-7 |
| Supply Ability: 10g | Release date: 2025/10/27 |
Product Introduction
Bioactivity
| Name | S-methyl DM1 |
| Description | S-methyl DM1, a thiomethyl derivative of Maytansine, binds to tubulin (Kd of 0.93 μM) and inhibits microtubule polymerization. |
| In vitro | S-methyl DM1, the primary cellular or liver metabolite of antibody-maytansinoid conjugates prepared with thiol-containing maytansinoids DM1[1], inhibits microtubule assembly at a half-maximal concentration of 4 μM. At 100 nM, S-methyl-DM1 (84%) suppresses dynamic instability more effectively than Maytansine (45%). Tritiated S-methyl-DM1 binds to 37 high-affinity sites per microtubule (Kd of 0.1 μM)[1]. Minimal inhibition occurs at 200 pM and is maximal at 3 nM. S-methyl DM1 (IC50 of 330 pM) is slightly more potent than Maytansine (IC50 of 710 pM)[2]. In MCF7 cells, S-methyl DM1 induces up to 80% accumulation of cells in G2/M compared to 30% in controls[2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | Tubulin | S-methyl DM-1 | S-methyl DM1 | Smethyl DM1 | S methyl DM1 | MicrotubuleAssociated | Microtubule Associated | ADCCytotoxin | ADC Cytotoxin |
| Inhibitors Related | Methotrexate | Flubendazole | N-Phenylbenzylamine | Mebendazole | Camptothecin | 4-Isopropoxybenzoic acid | Oxfendazole | Dexamethasone | Methylene Blue trihydrate | Griseofulvin | Paclitaxel | 4'-Demethylepipodophyllotoxin |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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