Product Details
| Product Name:
S65487 |
CAS No.:
1644600-79-2 |
| Purity:
99.03% |
Supply Ability:
10g |
| Release date:
2025/11/04 |
Product Introduction
Bioactivity
| Name | S65487 |
| Description | S65487 (VOB560) is a potent and selective inhibitor of the anti-apoptotic protein Bcl-2, displaying activity not only against the wild-type protein but also against clinically relevant BCL-2 mutations such as G101V and D103Y. S65487 demonstrates poor affinity toward other Bcl-2 family members, including MCL-1, BFL-1, and BCL-XL, which underlines its selectivity profile. S65487 induces apoptosis in cancer cells and exhibits robust anticancer activities in preclinical studies. |
| In vitro | S65487 effectively induces apoptosis and inhibits proliferation in a panel of hematologic cancer cell lines by binding to the BH3 hydrophobic groove of the BCL-2 protein, with a half-maximal inhibitory concentration (IC50) in the low nanomolar (nM) range. [1] |
| In vivo | S65487 effectively induces complete regression in BCL-2-dependent RS4;11 tumors through a single intravenous (IV) dose and demonstrates consistent, strong tumor regression in mouse and rat xenograft models of lymphoid malignancies at tolerable doses with weekly IV administrations when combined with MCL-1-specific inhibitor S64315/MIK665.[1] |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 5 mg/mL (6.97 mM), Sonication is recommended.
DMSO : 160 mg/mL (223.07 mM), Sonication is recommended.
|
| Keywords | S-65487 | S65487 | S 65487 |
| Inhibitors Related | Stavudine | Cysteamine hydrochloride | Sodium 4-phenylbutyrate | Metronidazole | Citric Acid Triammonium | Tributyrin | L-Methionine | Sodium citrate | Cystamine dihydrochloride | L-Ascorbic acid sodium salt | Alginic acid | Dextran sulfate sodium salt (MW 5000) |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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Recommended supplier
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Price |
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Suppliers |
Update time |
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$/ |
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Anhui Ruihan Technology Co., Ltd
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2023-08-21 |
United States