SB-224289 hydrochloride NEW
| Price | $85 | $123 | $225 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-10-23 |
Product Details
| Product Name: SB-224289 hydrochloride | CAS No.: 180084-26-8 |
| Purity: 98.09% | Supply Ability: 10g |
| Release date: 2025/10/23 |
Product Introduction
Bioactivity
| Name | SB-224289 hydrochloride |
| Description | SB-224289 hydrochloride (SB-224289A) is a selective antagonist of 5-HT1B receptor, with anxiolytic effect. |
| In vitro | SB-224289 demonstrates specific toxin-blocking properties without directly inhibiting the PS synthase enzyme or Cho1p in vitro. It consistently shows efficacy in producing Pap-A resistance at concentrations ranging from 100 μM to 25 μM and uniquely blocks the activity of papuamides, without affecting other membrane disruptors. Although SB-224289 does not protect wild-type cells from KF, it offers protection against TPap-A. It possesses a high affinity, with a pKi of 8, for human cloned 5-HT1B receptors, showing greater than 80-fold selectivity compared to the 5-HT1D receptor and other receptor types. As a potent antagonist (with a pEC50 of 7.9±0.1), SB-224289 induces a rightward shift in the 5-HT concentration response curve (with a pA2 of 8.4±0.2) and significantly enhances [3H]-5HT release in electrically stimulated guinea-pig brain cortex slices at 100 nM and 1 μM concentrations. |
| In vivo | SB 224289 is a potent antagonist with an ED50 of 3.6 mg/kg, p.o in SK&F-99101-induced hypothermia in the guinea-pig. SB 224289 (4 mg/kg, p.o) reverses sumatriptan-induced inhibition of 5-HT release showing that it is also a potent terminal 5-HT autoreceptor antagonist in vivo. SB 224289 (2-16 mg/kg, p.o) does not increase 5-HT levels in the fuinea-pig frontal cortex. However, SB 224289 (4 mg/kg, p.o) causes a significantly increase in levels of 5-HT in the fuinea-pig dentate gyrus[3]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 8.1 mg/mL (14.5 mM), Sonication and heating to 60℃ are recommended. |
| Keywords | SB-224289 Hydrochloride | SB224289 Hydrochloride | SB 224289 Hydrochloride | 5HTReceptor | 5-HT1B Receptor | 5-HT1B | 5HT Receptor |
| Inhibitors Related | Alverine citrate | Olanzapine | Dapoxetine hydrochloride | Clozapine N-Oxide | Mirtazapine | D-Menthol | Amitriptyline hydrochloride | Cloperastine hydrochloride | Trazodone hydrochloride | Mianserin hydrochloride | Fluoxetine hydrochloride | Cinchonidine |
| Related Compound Libraries | Pain-Related Compound Library | Bioactive Compound Library | Neuronal Signaling Compound Library | Anti-Alzheimer's Disease Compound Library | Membrane Protein-targeted Compound Library | Neurotransmitter Receptor Compound Library | Angiogenesis related Compound Library | Inhibitor Library | Bioactive Compounds Library Max | GPCR Compound Library | Anti-Cancer Compound Library | Serotonin Receptor-Targeted Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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