Product Details
| Product Name:
Se-Aspirin |
CAS No.:
1850293-95-6 |
| Purity:
98.07% |
Supply Ability:
10g |
| Release date:
2025/09/17 |
Product Introduction
Bioactivity
| Name | Se-Aspirin |
| Description | Se-Aspirin (Se-NSAID-8) has anticancer activity and gastroprotective effects, inhibits activation of proinflammatory and pro-survival NF-ĸB pathways, and inhibits the expression of anti-apoptotic targets downstream of NF-ĸB (e.g., Bcl-xL, Mcl-1, and survivin).Se-Aspirin induces Cell cycle arrest and activation of apoptosis accelerates ulcer healing and can be used to study pancreatic and colorectal cancer. |
| In vitro | Aspirin inhibits COX-1 and COX-2 in human articular chondrocytes with IC50 values of 3.57 μM and 29.3 μM, respectively[1]; Aspirin acetylates serine 530 of COX-1, thereby blocking the synthesis of thromboxane A in platelets and reducing platelet aggregation; Aspirin inhibits COX-2 protein expression by interfering with the binding of CCAAT/enhancer protein beta (C/EBPbeta) to its homologous sites on the COX-2 promoter/enhancer[2]; Aspirin inhibits NF-κB-dependent transcription from the lgκ enhancer and long terminal repeat (LTR) in human immunodeficiency virus (HIV)-transfected T cells[3]; Aspirin inhibits mitochondrial cytochrome c release, activation of p38 MAP kinase, and activation of the ceramide pathway[4]. |
| In vivo | Aspirin (5-150 mg/kg, PO, once) displays significant antipyretic activity in adult yeast-fever male rats. [5] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | SeAspirin | Se Aspirin | Mcl-1 | Bcl-xL | Apoptosis |
| Inhibitors Related | Stavudine | 5-Fluorouracil | Flubendazole | Cysteamine hydrochloride | Myricetin | Sodium 4-phenylbutyrate | L-Ascorbic acid | L-Glutamic acid | Tributyrin | L-Ascorbic acid sodium salt | Alginic acid | Dextran sulfate sodium salt (MW 5000) |
| Related Compound Libraries | Apoptosis Compound Library | Bioactive Compound Library | Bioactive Compounds Library Max | Anti-Cancer Active Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States