Seocalcitol NEW
| Price | $667 | $2790 |
| Package | 1mg | 5mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-08-21 |
Product Details
| Product Name: Seocalcitol | CAS No.: 134404-52-7 |
| Supply Ability: 10g | Release date: 2025/08/21 |
Product Introduction
Bioactivity
| Name | Seocalcitol |
| Description | Seocalcitol is an analog of vitamin D, binds vitamin D receptor protein from human osteosarcoma MG-63 cells(Kd : 0.27 nM). |
| In vitro | Seocalcitol is a stimulators of osteoclast recruitment in murine bone marrow cultures(EC50 at 0.1 nM). Seocalcitol stimulates bone resorption(EC50 of 0.03 nM)[1]. Seocalcitol elicites a dose-dependent induction of 24-hydroxylase mRNA in the kidney (EC50=0.4±0.13). In the kidney, Kd values for Seocalcitol is 0.48±0.04 nM. However, in the intestine, the Kd for Seocalcitol is 1.43±0.19 nM)[2]. Seocalcitol (0.1-10 nM) induces cell differentiation in a dosedependent manner. A higher differentiating activity is observed for 1 nM Seocalcitol than for 1 nM VD3. |
| In vivo | Seocalcitol, a synthetic vitamin D analog, demonstrates lower hypercalcemic activity compared to 1,25(OH)2VD3. Its long-term intraperitoneal (IP) administration at 0.5 μg/kg body weight bi-daily significantly inhibits hepatocellular carcinoma (HCC) development in C3H/Sy mice[4]. Furthermore, when administered intraperitoneally to postnatal rats from days 4 to 12 at dosages of 0.38 or 1.25 μg/kg body weight per day, only the higher dosage (1.25 μg/kg) significantly attenuates weight gain, either as a standalone treatment or when combined with Dexamethasone, all-trans retinoic acid (RA), or retinoic acid[5]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 50 mg/mL (109.97 mM), Sonication is recommended. |
| Keywords | vitamin D receptor | Seocalcitol | EB-1089 | EB1089 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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