SLM6031434 HCl NEW
| Price | $128 | $418 | $575 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: SLM6031434 HCl | CAS No.: 1897379-34-8 |
| Supply Ability: 10g | Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | SLM6031434 HCl |
| Description | SLM6031434 HCl is a SphK2 inhibitor with anti-fibrotic effects that reduces LPS-induced TNFα and IL-1β production and can be used to study renal fibrosis. |
| In vitro | b>METHODS: U937 cells exposed to 1 μM FTY720 were treated with concentrations of SLM6031434 HCl (0.1, 0.3 μM, 2 hours), harvested by centrifugation and processed for LC/MS. RESULTS: SLM6031434 HCl blocked FTY720 phosphorylation in cultured U937 cells. [1] |
| In vivo | b>METHODS: SLM6031434 HCl (10 mg/kg, intraperitoneal injection) was administered to mice lacking a functional SphK1 allele (Sphk1−/−) /SphK2 deficient (Sphk2−/−) and whole blood was processed for LC/MS analysis. RESULTS: Administration of SLM6031434 HCl to mice lacking a functional SphK1 allele (Sphk1−/−) resulted in a decrease in blood S1P; SLM6031434 HCl did not affect blood S1P concentrations in SphK2 deficient (Sphk2−/−) mice. [1] |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | H2O : 30 mg/mL (61.23 mM), Sonication is recommended. |
| Keywords | SLM 6031434 | SLM-6031434 | SLM6031434 HCl | SLM6031434 |
| Inhibitors Related | Fingolimod hydrochloride | SLP9101555 | SKI-178 | LX-2931 | K145 hydrochloride | ASP-4058 | Ceranib-2 | Siponimod | MP-A08 | Ozanimod |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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