Sodium Deoxycholate NEW

Sodium Deoxycholate (NaDOC) is a bile salt derivative with detergent-like properties, widely used in biochemical, pharmaceutical, and industrial applications due to its ability to solubilize lipids and disrupt cell membranes. Below are its key applications:  

1. Biological & Biochemical Research

- Cell Lysis & Protein Extraction:  

  - Mild detergent for breaking cell membranes (e.g., in mitochondria/plasma membrane isolation).  

  - Solubilizes membrane proteins and lipoproteins.  

- Nucleic Acid Purification:  

  - Removes lipids/proteins during DNA/RNA extraction (e.g., in plasmid prep kits).  

- Viral Studies:  

  - Disrupts viral envelopes (e.g., influenza, hepatitis B) for structural analysis.  

2. Pharmaceutical & Medical Uses 

- Drug Delivery:  

  - Enhances absorption of hydrophobic drugs (e.g., anticancer agents).  

- Antimicrobial Agent:  

  - Disrupts bacterial membranes (limited use in topical formulations).  

- Cholesterol & Gallstone Research:  

  - Mimics bile composition to study cholesterol crystallization.  

3. Diagnostic & Laboratory Reagents  

- Immunoassays (ELISA/Western Blot):  

  - Reduces nonspecific binding in antibody-based assays.  

- Protein Crystallization:  

  - Additive to optimize crystal formation.