Product Details
| Product Name:
SP187 |
CAS No.:
615253-61-7 |
| Purity:
99.18% |
Supply Ability:
10g |
| Release date:
2025/11/09 |
Product Introduction
Bioactivity
| Name | SP187 |
| Description | SP187 (MON-DNJ) is a host-targeted iminosugar. It has anti-filovirus infection activity.SP187 is used for therapeutic use against influenza and dengue viruses. |
| In vitro | SP187 (UV-4) is evaluated in vitro for its antiviral efficacy against EBOV and MARV using a yield-plaque assay format. SP187 demonstrates antiviral activity with IC50 values of 29.97 μM and 47.72 μM against EBOV and MARV, respectively.[1] |
| In vivo | In this study, C57Bl/6 mice are administered 10 or 100 mg/kg of SP187 or UV-5 via oral gavage or IP injection. Dosing started ~1h before infection with ~1000 pfu of mouse-adapted EBOV and is repeated BID for 10 days at approximately 12-hour intervals for UV-5 or TID at approximately 8-hour intervals for SP187. The selected doses and schedules are based on tolerability studies in naïve mice. No efficacy is observed in the iminosugar-treated mice as compared to the vehicle control.[1] |
| Storage | keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (6.26 mM), Sonication is recommended.
DMSO : 63.89 mg/mL (200.01 mM), Sonication is recommended.
|
| Keywords | VirusProtease | Virus Protease | UV-4 | UV 4 | SP-187 | SP187 | SP 187 | MON-DNJ | MARV | InfluenzaVirus | Influenza Virus | Influenza virus | Filovirus | EBOV | Dengue Fever virus |
| Inhibitors Related | Phenytoin sodium | Acetylcysteine | Nitazoxanide | L-Lysine | Penicillin G potassium | Curcumin | Ofloxacin | (E)-3-(p-Tolyl)acrylaldehyde | Thymidine | Naringenin | Salcomine | Dihydromyricetin |
| Related Compound Libraries | Bioactive Compound Library | Anti-Viral Compound Library | Bioactive Compounds Library Max | Anti-Infection Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States