(S,R,S)-AHPC-C6-PEG3-C4-Cl NEW
| Price | $61 | $98 |
| Package | 2mg | 5mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-07-20 |
Product Details
| Product Name: (S,R,S)-AHPC-C6-PEG3-C4-Cl | CAS No.: 1835705-55-9 |
| Supply Ability: 10g | Release date: 2025/07/20 |
Product Introduction
Bioactivity
| Name | (S,R,S)-AHPC-C6-PEG3-C4-Cl |
| Description | (S,R,S)-AHPC-C6-PEG3-C4-Cl is a small molecule HaloPROTAC incorporating the (S,R,S)-AHPC based VHL ligand and a 3-unit PEG linker, capable of inducing the degradation of GFP-HaloTag7 in cell-based assays[1]. |
| In vitro | The chemical compound '(S,R,S)-AHPC-C6-PEG3-C4-Cl' utilizes the cereblon ligand[1] and features a 6-2-2-6 linker, incorporating both hydrophobic and hydrophilic elements to achieve a balanced hydrophilicity/hydrophobicity in the resultant compounds. This compound forms the basis for developing PROTACs aimed at degrading the oncogenic tyrosine kinase BCR-ABL. It is engineered to attach to potent TKIs, specifically bosutinib and dasatinib, facilitating the degradation of c-ABL and BCR-ABL by exploiting either CRBN or VHL E3 ubiquitin ligase mechanisms[2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 100 mg/mL (133.08 mM), Sonication is recommended. |
| Keywords | VHL | AHPC-C6-PEG3-C4-Cl | (S,R,S)-AHPC-C-6-PEG3-C4-Cl | (S,R,S)AHPCC6PEG3C4Cl | (S,R,S) AHPC C6 PEG3 C4 Cl |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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