TAS-114 NEW
| Price | $299 |
| Package | 2mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-08-30 |
Product Details
| Product Name: TAS-114 | CAS No.: 1198221-21-4 |
| Purity: 99.76% | Supply Ability: 10g |
| Release date: 2025/08/30 |
Product Introduction
Bioactivity
| Name | TAS-114 |
| Description | TAS-114 is an orally active dual inhibitor of dUTPase and dihydropyrimidine dehydrogenase (DPD). TAS-114 targets the intercellular metabolism of 5-FU to enhance antitumor activity and modulates catabolic pathways to improve the systemic availability of 5-FU. |
| In vitro | In HeLa, NUGC-4, NCI-H441, HT-29, CFPAC-1, and MCF-7 cell lines, TAS-114 (72 hours; 1 μM, 3 μM, and 10 μM) can significantly enhance the cytotoxicity of FdUrd and 5-FU against various cancer cell lines in a dose-dependent manner[1]. |
| In vivo | In BALB/c nude mice with MX-1 human breast cancer xenografts, TAS-114 (37.5 to 1200 mg/kg/day; orally; daily; 1-14 days) can decrease the tolerable doses of Capecitabine (539 mg/kg/day) in a dose-dependent manner in mice[1]. |
| Storage | store at low temperature,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 80 mg/mL (177.17 mM), Sonication is recommended. |
| Keywords | TAS-114 | dUTPase, DPD | dihydropyrimidine dehydrogenase (DPD) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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