Tigilanol tiglate NEW
| Price | Get Latest Price |
| Package | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-10-17 |
Product Details
| Product Name: Tigilanol tiglate | CAS No.: 943001-56-7 |
| Supply Ability: 10g | Release date: 2025/10/17 |
Product Introduction
Bioactivity
| Name | Tigilanol tiglate |
| Description | Tigilanol tiglate (EBC-46) is a PKC/C1 domain activator. Tigilanol tiglate promotes mitochondrial/endoplasmic reticulum dysfunction, leading to ATP depletion, caspase activation, and gasdermin E cleavage. It induces immunogenic cell death, enhancing the response to immune checkpoint blockade in both target tumours and non-injected tumours, resulting in tumour regression. |
| In vitro | In MM649 and A-431 cancer cells, Tigilanol tiglate (300-500 µM, 1-12 hours) promotes the release or externalization of damage-associated molecular patterns (DAMPs) [1]. In H357 head and neck cancer cells, Tigilanol tiglate (1 µg/mL, 10 min-24 h) alters the secretome profile, thereby affecting c-met phosphorylation levels and the expression of cell surface proteins [3]. |
| In vivo | Tigilanol tiglate (66.5-533 μM, 50 μL) was intratumorally injected into BALB/c Foxn1nu nude mice, demonstrating rapid elimination of melanoma Parazanico Spilurus subsp. Spilurus xenograft tumors in a concentration-dependent manner [1]. Intratumoral injection of tigilanol tiglate (1 mg/mL, 0.5 mL per cm3 of tumor volume) showed significant therapeutic effects and effectively improved the condition of canine mast cell tumors [2]. |
| Storage | keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | Tigilanol tiglate | EBC 46 |
| Inhibitors Related | Ellagic acid | Darovasertib | α-Vitamin E | Ro-3306 | Piceatannol | Staurosporine | Methyl-Hesperidin | Mitoxantrone | Fasudil hydrochloride | N-Desmethyltamoxifen hydrochloride | Mitoxantrone dihydrochloride | R59949 |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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