TMPD dihydrochloride NEW

TMPD dihydrochloride

Modify Date: 2025-08-26 13:44:11

TMPD dihydrochloride structure	Common Name	TMPD dihydrochloride
	CAS Number	637-01-4	Molecular Weight	237.169
	Density	N/A	Boiling Point	260.6ºC at 760 mmHg
	Molecular Formula	C10H18Cl2N2	Melting Point	222-224 °C(lit.)
	MSDS	ChineseUSA	Flash Point	104.9ºC
	Symbol	GHS07	Signal Word	Warning

Purity		Quantity		Budget		Inquiry

Use of TMPD dihydrochloride TMPD dihydrochloride, a readily oxidizable compound, is an enzymatically convert redox active substrate molecule. TMPD dihydrochloride is also an electron donor and serves as a reducing cosubstrate for heme peroxidases[1][2]. TMPD dihydrochloride is also a complex IV substrate[3].

• Properties

• Articles3

• Spectrum

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 Names

Name	N,N,N',N'-Tetramethyl-p-phenylenediamine dihydrochloride
Synonym	More Synonyms

 TMPD dihydrochloride Biological Activity

Description	TMPD dihydrochloride, a readily oxidizable compound, is an enzymatically convert redox active substrate molecule. TMPD dihydrochloride is also an electron donor and serves as a reducing cosubstrate for heme peroxidases[1][2]. TMPD dihydrochloride is also a complex IV substrate[3].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
In Vitro	TMPD (N,N,N′,N′-tetramethyl-para-phenylene-diamine) is used in cell culture and microbiology to differentiate organisms that exhibit cytochrome c oxidase activity and to distinguish between Gram-negative and Gram-positive pathogenic and non-pathogenic bacteria. The concept of TMPD oxidation by microorganisms is widely used and is known as a successful colorimetric indicator for bacterial oxidases, as the radical cation TMPD+˙, formed by oxidation, shows a characteristic deep blue colour. The electrochemical recognition of the TMPD oxidation by bacterial oxidases can be applied to a variety of pathogens[1].
References	[1]. S Kuss, et al. Electrochemical recognition and quantification of cytochrome c expression in Bacillus subtilis and aerobe/anaerobe Escherichia coli using N, N, N', N'-tetramethyl- para-phenylene-diamine (TMPD). Chem Sci. 2017 Nov 1;8(11):7682-7688. [2]. Nenad Petrovic, et al. Using N,N,N',N'-tetramethyl-p-phenylenediamine (TMPD) to assay cyclooxygenase activity in vitro. Methods Mol Biol. 2010;594:129-40. [3]. Franco A Rossato, et al. Fatty acid synthase inhibitors induce apoptosis in non-tumorigenic melan-a cells associated with inhibition of mitochondrial respiration. PLoS One. 2014 Jun 25;9(6):e101060.

 Chemical & Physical Properties

Boiling Point	260.6ºC at 760 mmHg
Melting Point	222-224 °C(lit.)
Molecular Formula	C10H18Cl2N2
Molecular Weight	237.169
Flash Point	104.9ºC
Exact Mass	236.084702
PSA	6.48000
LogP	3.42260
Storage condition	Store at RT.
Stability	Stable. Incompatible with strong oxidizing agents, strong bases.
Water Solubility	SOLUBLE

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