Trifluoromethyl-tubercidin NEW
| Price | $47 | $108 | $196 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-11-10 |
Product Details
| Product Name: Trifluoromethyl-tubercidin | CAS No.: 1854086-05-7 |
| Purity: 99.90% | Supply Ability: 10g |
| Release date: 2025/11/10 |
Product Introduction
Bioactivity
| Name | Trifluoromethyl-tubercidin |
| Description | Trifluoromethyl-tubercidin (TFMT) inhibits host MTr1 and suppresses virus replication. TFMT inhibits MTr1 through interaction at its S-adenosyl-l-methionine binding pocket to restrict influenza virus replication. TFMT was effective in inhibiting viral replication in mice, displayed little toxicity. |
| In vitro | The median inhibitory concentration (IC50) for trifluoromethyl-tubercidin against IAV infection was 0.30 μM, and no notable in vitro toxicity was observed in the range of effective concentrations, as measured with water-soluble tetrazolium (WST)–8 cell viability assay. Trifluoromethyl-tubercidin treatment also greatly inhibited IAV replication when administered 3 to 4 hours after infection. Trifluoromethyl-tubercidin showed inhibitory activity in the IAV-infected mouse cell line LA-4, albeit with lower potency (IC50 = 7.7 μM) than in human cells[1]. |
| In vivo | Trifluoromethyl-tubercidin treatment at 2 days after infection with IAV. At this point, NP and PB2 mRNA levels were significantly reduced by trifluoromethyl-tubercidin treatment in mouse lungs, indicating that the trifluoromethyl substitution of tubercidin reduces in vivo toxicity to levels we could not detect, but retains anti-IAV efficacy[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 3.34 mg/mL (9.99 mM), Sonication is recommended. |
| Keywords | Trifluoromethyl-tubercidin | Trifluoromethyltubercidin | MTr1(host) | InfluenzaVirus | Influenza Virus |
| Inhibitors Related | Acetylcysteine | α-Vitamin E | Molnupiravir | AEBSF hydrochloride | Nitazoxanide | Camphor | Curcumin | N-Acetylneuraminic acid | Naringenin | Salcomine | Crystal Violet | β-Cyclodextrin |
| Related Compound Libraries | Bioactive Compound Library | Anti-Viral Compound Library | Inhibitor Library | Bioactive Compounds Library Max | Fluorochemical Library | Anti-Infection Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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