Product Details
| Product Name:
UNC-CA359 |
CAS No.:
2676156-05-9 |
| Supply Ability:
10g |
Release date:
2026/04/20 |
Product Introduction
Bioactivity
| Name | UNC-CA359 |
| Description | UNC-CA359 is a highly potent inhibitor of the epidermal growth factor receptor (EGFR), demonstrating an IC50 value of 18 nM. With strong anti-tumor activity, UNC-CA359 holds significant potential for chordoma research [1]. |
| In vitro | UNC-CA359, also referred to as compound 45, demonstrates varying levels of activity across different targets: it is ineffective against U-CH1, partially effective on U-CH2, and strongly inhibits EGFR with IC50 values of >100 μM, 35 μM, and 18 nM, respectively. When tested in chordoma cell lines for 72 hours at concentrations ranging from 1 nM to 0.1 mM, UNC-CA359 exhibits IC50 values of 1.2 μM in CH22 and 3.0 μM in U-CH12 cells. Furthermore, it targets three collateral kinases, showing notable potency towards SLK/STK10 with a selectivity ratio over NAK of 22. The binding constants (Ki) for GAK, SLK, and STK10 are 3.4 nM, 0.33 μM, and 0.075 μM, respectively. In a cytotoxicity assay involving various chordoma cell lines and WS1 cells, it showed promising activity against the chordoma cells with IC50 values of 1.2 μM (CH22), 3.0 μM (U-CH12), 60 μM (UM-Chor1), and 74 μM (U-CH7), while exhibiting no toxicity toward WS1 cells (IC50 >100 μM). |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Inhibitors Related | (S)-Afatinib | Osimertinib | Lidocaine Hydrochloride hydrate | Lapatinib | Erlotinib hydrochloride | Erlotinib | Neratinib | Afatinib | Chalcone | Brigatinib | Genistein | Gefitinib |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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