Wf-516 NEW
| Price | $1820 | $2380 | $3100 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-10-27 |
Product Details
| Product Name: Wf-516 | CAS No.: 310392-94-0 |
| Supply Ability: 10g | Release date: 2025/10/27 |
Product Introduction
Bioactivity
| Name | Wf-516 |
| Description | Wf-516 is a 5-HT reuptake inhibitor (Kis: 5 nM and 40 nM for 5-HT1A receptor and 5-HT2A receptor in humans, respectively), and with potent antidepressant activity. |
| In vitro | WF-516 exhibits high affinity for 5-HT1A receptors in the hippocampus and raphe nucleus of rats (Ki of 8.1 nM and 7.9 nM, respectively) [2]. |
| In vivo | Wf-516 (0.5 mg/kg, i.v.) does not alter the firing activity of 5-HT neurons but significantly inhibits the effect of 8-OHDPAT (a 5-HT autoreceptor agonist) by 70%. The suppression of DRN firing activity by LSD experienced a significant fourfold rightward shift in Wf-516 pretreated rats (ED50 = 32.4 ± 1.0 μg/kg) compared to controls (ED50 = 7.5 ± 1.2 μg/kg). Successive intravenous doses of Wf-516 (up to 10 mg/kg) prolong the effect of microiontophoretically applied 5-HT, achieving statistical significance at 7.5 mg/kg, with RT50 values increased by 53% and 75% at 7.5 mg/kg and 10 mg/kg, respectively. Oral administration of 30 mg/kg Wf-516 to 5,7-DHT-treated rats resulted in a significant decrease in hippocampal BPND, with no further decrease in the grooved nuclei; ED50 values were 5.3 mg/kg in the hippocampus and 4.2 mg/kg in the grooved nuclei. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | Wf-516 | Wf516 | Wf 516 | Human 5-HT2A receptor | Human 5-HT1A receptor | 5HTReceptor | 5HT Receptor |
| Inhibitors Related | Alverine citrate | Sevoflurane | Dapoxetine hydrochloride | Cefaclor monohydrate | Clozapine N-Oxide | Mirtazapine | 1,8-Cineole | Venlafaxine hydrochloride | Cloperastine hydrochloride | Trazodone hydrochloride | Mianserin hydrochloride | Cinchonidine |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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TargetMol Chemicals Inc.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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