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Postion:Product Catalog >Xanomeline Sulfone
Xanomeline Sulfone
  • Xanomeline Sulfone
  • Xanomeline Sulfone
  • Xanomeline Sulfone
  • Xanomeline Sulfone
  • Xanomeline Sulfone

Xanomeline Sulfone NEW

Price Get Latest Price
Package 10mg 50mg 100mg
Min. Order: 10mg
Supply Ability: 1000
Update Time: 2025-06-19

Product Details

Product Name: Xanomeline Sulfone Min. Order: 10mg
Purity: 99%+ HPLC Supply Ability: 1000
Release date: 2025/06/19
Molecular formula: C14H23N3O3S

Xanomeline Sulfone

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WhatsAPP: +86 17386083646
E-mail: anna@molcoo.com

Product Information

  • Product Code:X002022

  • English Name:Xanomeline Sulfone

  • English Alias:3-(hexyloxy)-4-(1-methyl-1,2,5,6-tetrahydropyridin-3-yl)-1,2,5-thiadiazole 1,1-dioxide

  • CAS No.:Not provided

  • Molecular Formula:C₁₄H₂₃N₃O₃S

  • Molecular Weight:313.42

Advantages

  • High-Purity Reference Standard:Confirmed by HPLC (≥99.0%), NMR (1H, 13C), HRMS, and elemental analysis, providing an accurate standard for Xanomeline-related impurity analysis.

  • Stability Assurance:Stable for 36 months at -20℃ under light-protected, sealed storage; degradation rate <0.3% in methanol-water mixture within 6 months.

Applications

  • Quality Control Testing:Used for UPLC-MS/MS detection of sulfone impurities in Xanomeline API and formulations, controlling content to meet ICH Q3A standards (single impurity limit ≤0.1%).

  • Process Optimization Research:Monitors the formation pathway of this sulfone impurity during Xanomeline synthesis or storage. Optimizing oxidation conditions (e.g., avoiding strong oxidants, controlling temperature ≤20℃) reduces impurity generation by >40%.

  • Method Validation:Serves as a standard for developing sulfone impurity detection methods, verifying UPLC resolution (≥3.0) and LOD (0.01 ng/mL).

Background Description

Xanomeline, a selective muscarinic M1 receptor agonist, treats Alzheimer's disease by enhancing cholinergic function. Xanomeline Sulfone, an oxidative degradation impurity, may originate from excessive oxidation of the thiadiazole ring sulfur (e.g., exposure to strong oxidants or long-term light during storage). Its sulfone group (-SO₂-), tetrahydropyridine ring, and hexyloxy group may affect drug hydrophilicity, metabolic pathways, and blood-brain barrier permeability. Strict impurity control is critical for CNS drugs, making research on this impurity essential for drug quality.

NOTE!

We can also customize related analogues and modified peptides including HPLC, MS, 1H-NMR, MS, HPLC, IR, UV, COA, MSDS.
This product is intended for laboratory use only!

WhatsAPP: +86 17386083646
E-mail: anna@molcoo.com


NEW IN STOCK!

The Molcoo Laboratory added drug impurity reference standards, including Baricitinib, Piperazine, Benzylpenicillin, Tranilast and multiple N-Nitroso drug impurities! Now available for immediate delivery! 



Company Profile Introduction

1. Drug standards and drug impurity reference substances: provide more than 20,000 kinds of spot impurity reference substances, with sufficient supply and same-day delivery. We have a professional R&D team and comprehensive quality control testing to ensure product quality and reliability. 2. Customized synthesis of impurities and new molecules: Quickly respond to the customized needs of CDE impurities, stably supply impurities that have established quality standards, and provide customized synthesis services for new compounds in the research and development of innovative drugs. 3. Preparation and separation of unknown impurities: With a professional impurity preparation and separation technical team and SFC preparation and separation instruments, we can solve the problems of impurity preparation in complex projects. 4. Process development of new drug intermediates: provide the supply of new drugs and new molecular impurities, process optimization services, as well as the screening and impurity analysis of commercialization routes. 5. Peptide synthesis: Provide customized peptide synthesis services, and cover all kinds of degradation impurities and process impurities generated in the research and development of peptide drugs. At the same time, it provides comprehensive structural confirmation data and customized testing services.

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