Product Details
| Product Name:
XY028-140 |
CAS No.:
2229974-83-6 |
| Purity:
98.59% |
Supply Ability:
10g |
| Release date:
2025/10/26 |
Product Introduction
Bioactivity
| Name | XY028-140 |
| Description | XY028-140 is a selective CDK4/CDK6 degrade and inhibits both CDK4/6 expression and activity in cancer cells. XY028-140 is a PROTAC connected by ligands for Cereblon and CDK. |
| In vitro | In A375 melanoma and T47D breast cancer cells, XY028-140(0.3 or 1 µΜ for 24h) inhibited both CDK4/6 expression and CDK4/6 activity. In T47D breast cancer cells, XY028-140(0.03, 0.1, 0.3, 1, or 3 µΜ for 11d) inhibited cancer cell proliferation in breast cancer cells[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 5 mg/mL (6.57 mM), Sonication and heating to 60℃ are recommended.
|
| Keywords | XY-028-140 | XY028140 | XY028 140 | PROTACs | Inhibitor | inhibit | Cyclin dependent kinase | Cereblon | CDK6 | CDK4 | CDK | anticancer |
| Inhibitors Related | Ribociclib | Ro-3306 | Abemaciclib | ARV-471 | Rafoxanide | Palbociclib monohydrochloride | CASIN | Palbociclib | GW 441756 | Sodium Oxamate | Dinaciclib | Abemaciclib methanesulfonate |
| Related Compound Libraries | Bioactive Compound Library | Kinase Inhibitor Library | Anti-Breast Cancer Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Cell Cycle Compound Library | Anti-Cancer Compound Library | Anti-Cancer Active Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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