Yoda 1 NEW
| Price | $39 | $55 | $87 |
| Package | 1mg | 2mg | 5mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-11-08 |
Product Details
| Product Name: Yoda 1 | CAS No.: 448947-81-7 |
| Purity: 98.00% | Supply Ability: 10g |
| Release date: 2025/11/08 |
Product Introduction
Bioactivity
| Name | Yoda 1 |
| Description | Yoda 1 is an agonist of the Piezo1 channel that agonizes human- and mouse-derived Piezo1 (EC50=17.1/26.6 μM). Yoda 1 is also an inhibitor of glycine transporter protein 2 (GlyT2). |
| In vitro | METHODS: HEK293T cells transiently transfected with mouse and human Piezo1 and Piezo2 were treated with Yoda 1 (0-100 µM) and concentration response curves were examined by FLIPR. RESULTS: Micromolar concentrations of Yoda1 induced a strong Ca2+ response in cells transfected with human or mouse Piezo1, but not in cells transfected with Piezo2, suggesting selectivity for Piezo1. The apparent EC50 of mouse and human Piezo1 was 17.1 µM and 26.6 µM, respectively.[1] METHODS: HUVEC cells were cultured under laminar flow at a constant shear stress of 5dyn/cm2 or under static conditions of Yoda 1 (0.05-2 µM) for 24 h. The surface levels of ICAM-1 or VCAM-1 were measured by flow cytometry. RESULTS: Incubation under constant shear stress increased surface expression of ICAM-1 by an average of 1.77±0.19-fold, but not VCAM-1. 24 h of Yoda 1 treatment mimicked this response, inducing a concentration-dependent increase in ICAM-1 surface expression. 1 µM Yoda 1 significantly increased ICAM-1 levels by 1.45±0.11-fold over the control, while VCAM-1 surface expression was unaffected. [2] |
| In vivo | METHODS: To study the effects on osteoblasts, Yoda 1 (5 µmol/kg) was injected intraperitoneally into C57BL/6J mice five times per week for two weeks. RESULTS: Yoda 1 did not alter body weight, but increased cortical thickness and cancellous bone mass in the distal femur. Yoda 1 also increased cortical thickness in the vertebrae, with no detectable change in cancellous bone volume in the vertebrae. Consistent with the effects on bone mass, serum osteocalcin (a marker of bone formation) levels were elevated in Yoda 1-treated mice. Yoda 1 activation of Piezo1 mimicked the effects of fluid shear stress on osteoblasts and increased bone mass in the mice. [3] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2.8 mg/mL (7.88 mM), Solution. DMSO : 28 mg/mL (80 mM), Sonication is recommended. |
| Keywords | Yoda-1 | Yoda1 | Yoda 1 | Protein kinase B | Potassium Channel | PKB | PiezoChannel | Piezo1 ion channel | Piezo1 | Piezo Channel | KcsA | Inhibitor | inhibit | HCAECs | Extracellular signal regulated kinases | ERK1/2 | ERK | Endothelial cells | Akt | A431 cells |
| Inhibitors Related | TBHQ | Minoxidil sulfate | Musk ketone | Hydrochlorothiazide | 1,8-Cineole | Artemisinin | Tauroursodeoxycholate | Minoxidil | 2,3-Butanediol | Chlorzoxazone | β-Glycerophosphate disodium salt hydrate | Indapamide |
| Related Compound Libraries | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Neuroprotective Compound Library | NO PAINS Compound Library | Bioactive Compounds Library Max | Ion Channel Targeted Library | Anti-Cancer Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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