Zolmitriptan Impurity 34 NEW

Zolmitriptan Impurity 34;114094-45-0

WhatsAPP: +86 17386083646
E-mail: anna@molcoo.com

Product Information

• Product Number: Z004034

• English Name: Zolmitriptan Impurity 34

• English Alias: 4,4-diethoxy-N-methylbutan-1-amine

• CAS Number: 114094-45-0

• Molecular Formula: C₉H₂₁NO₂

• Molecular Weight: 175.27

Advantages

• Well-defined with distinct functional groups: Contains a diethoxy acetal, N-methylamine, and butane chain, differing from zolmitriptan by lacking the indoline core. Acetal polarity and amine basicity enable clear differentiation via GC or reversed-phase HPLC as a specific impurity marker;

• High stability and traceability: Acetal structure is stable under neutral conditions. As an intermediate from incomplete reduction of amino acetal in zolmitriptan synthesis, it directly reflects amine intermediate purity pre-indoline formation, improving process tracing accuracy;

• High detection sensitivity: Amine protonation enhances GC response, combined with characteristic mass response (m/z 176 [M+H]⁺), enabling trace analysis (ppb level) via GC-MS, compatible with amino acetal impurity systems.

Applications

• Pharmaceutical quality control: Used as an impurity reference standard to quantify Zolmitriptan Impurity 34 in APIs, ensuring residual amino acetal intermediates meet quality standards post-reduction/indoline cyclization;

• Synthesis optimization: Optimizing acetal reduction (reducing agent dosage) by monitoring impurity levels to enhance indoline ring formation efficiency;

• Intermediate purity assessment: Evaluating purity of key amino acetal intermediates in zolmitriptan synthesis to support specificity of downstream cyclization.

Background Description

Research Status

• Analytical method validation: Developing GC-MS assays with weakly polar columns for baseline separation, achieving 0.5 ppb detection limits;

• Reduction kinetics: Studying impurity formation under varying reducing agent concentrations to clarify amino acetal-to-indoline conversion mechanisms;

• Process refinement: Controlling impurity levels below 0.1% via optimized catalyst dosage to enhance API purity;

• Structural confirmation: Using ¹H/¹³C-NMR to verify acetal/amine structure, distinguishing from zolmitriptan’s indoline core for impurity identification

We can also customize related analogues and modified peptides including HPLC, MS, 1H-NMR, MS, HPLC, IR, UV, COA, MSDS.
This product is intended for laboratory use only!

WhatsAPP: +86 17386083646
E-mail: anna@molcoo.com