Product Name：IAβ5
CAS No.：182912-74-9
Synonyms：Beta-Sheet Breaker Peptide iAβ5;[Pro18, Asp21] β - Amyloid (17-21), iAb5；淀粉蛋白样肽17-21
Catalog No.：107P114
Brand：HongTide（上海鸿肽生物）
Description：Beta-Sheet Breaker Peptide iAβ5是由5个氨基酸组成的多肽，已被证明可抑制大鼠脑模型中的淀粉样蛋白生成。研究表明，β-折叠破坏肽可显着减少体内淀粉样蛋白 β-蛋白沉积，并在淀粉样变性大鼠脑模型中完全阻断淀粉样蛋白原纤维的形成。 目前的证据支持这样一种观点，即 β-淀粉样蛋白沉积物或 Abeta 中间体可能是阿尔茨海默病 (AD) 患者发病机制的原因。 由于其抑制脑淀粉样蛋白 β 蛋白沉积，Beta-Sheet Breaker Peptide 似乎是阿尔茨海默病治疗的重要靶点。
Beta-Sheet Breaker Peptide iA β 5 is a peptide composed of 5 amino acids, which has been proven to inhibit amyloid protein production in rat brain models. Research shows, β- Folding disruption peptides can significantly reduce amyloid protein in the body β- Protein deposition completely blocks the formation of amyloid fibrils in a rat brain model of amyloidosis. The current evidence supports the view that β- Amyloid protein deposits or Abeta intermediates may be the cause of the pathogenesis of Alzheimer's disease (AD) in patients. Due to its inhibition of brain amyloid protein β Protein deposition, Beta Sheet Breaker Peptide, seems to be an important target for the treatment of Alzheimer's disease.
Purity (HPLC) ≥98.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility：H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(1-letter code) | LPFFD |
Sequence(3-letter code) | H-Leu-Pro-Phe-Phe-Asp-OH |
Peptide Structure | 
|
Molecular Formula | C33H43N5O8 |
Molecular Weight | 637.73 |
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关键字： IAβ5;182912-74-9;淀粉蛋白样肽17-21;多肽;多肽合成;
上海鸿肽生物科技有限公司（简称：鸿肽生物）是一家以多肽以及多肽上下游产品研发、生产、销售以及技术转让为主要业 务科技公司。公司现有产品涵盖：定制多肽、目录多肽、氨基酸衍生物、小分子化合物；公司自成立以来，秉持“用质量作船， 以服务为帆，为科研服务”的企业理念，为国内外众多科研工作者提供了优质的服务及产品。