aladdin 阿拉丁 M414228 Mavacamten (MYK-461) 1642288-47-8 99%

中文名：Mavacamten (MYK-461)

英文名：Mavacamten (MYK-461)

纯度：Moligand™，≥99%

货号：M414228

Cas号：1642288-47-8

存储温度：-20°C储存

运输条件：超低温运输

产品介绍：

Information

Mavacamten (MYK-461) Mavacamten (MYK-461, SAR439152) is a small-molecule modulator of cardiac myosin that targets the underlying sarcomere hypercontractility of hypertrophic cardiomyopathy (HCM), one of the most prevalent heritable cardiovascular disorders.

In vitro

MYK-461 primarily reduces the steady-state ATPase activity by inhibiting the rate of phosphate release of β-cardiac myosin-S1. MYK-461 modulates multiple steps of the myosin chemomechanical cycle. In addition to decreasing the rate-limiting step of the cycle (phosphate release), MYK-461 reduces the number of myosin-S1 heads that can interact with the actin thin filament during transition from the weakly to the strongly bound state without affecting the intrinsic rate. MYK-461 also decreases the rate of myosin binding to actin in the ADP-bound state and the ADP-release rate from myosin-S1 alone.

In vivo

Early, chronic administration of MYK-461 suppresses the development of ventricular hypertrophy, cardiomyocyte disarray, and myocardial fibrosis and attenuates hypertrophic and profibrotic gene expression in mice harboring heterozygous human mutations in the myosin heavy chain.

查看阿拉丁官网此产品相关对应页面：https://www.aladdin-e.com/zh_cn/M414228.html