MAGEA6抗体,Rabbit Polyclonal MAGEA6 Antibody
  • MAGEA6抗体,Rabbit Polyclonal MAGEA6 Antibody
  • MAGEA6抗体,Rabbit Polyclonal MAGEA6 Antibody
  • MAGEA6抗体,Rabbit Polyclonal MAGEA6 Antibody

Rabbit Polyclonal MAGEA6 Antibody

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-09
QQ交谈 微信洽谈

产品详情

中文名称:MAGEA6抗体英文名称:Rabbit Polyclonal MAGEA6 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 72 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: MAGEA6
2025-05-09 MAGEA6抗体 Rabbit Polyclonal MAGEA6 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 72 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/2000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesCT1.6; MAGE6; MAGE3B; MAGE-3b
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human MAGEA6
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P04090(MAGEA6 Antibody) at dilution 1/120. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P04090(MAGEA6 Antibody) at dilution 1/120. (Original magnification: ×200)    


           

参考文献

以下是关于 **MAGEA6抗体** 的3篇参考文献概览(示例为虚构文献,仅供参考格式):

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1. **文献名称**: *MAGEA6 promotes hepatocellular carcinoma progression via ubiquitination of p53*

**作者**: Li X, Zhang Y, et al.

**摘要**: 该研究利用MAGEA6抗体通过免疫共沉淀(Co-IP)和Western blot技术,揭示了MAGEA6通过介导p53蛋白的泛素化降解促进肝癌细胞增殖和转移的分子机制。

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2. **文献名称**: *MAGEA6 as a novel biomarker for melanoma immunotherapy response*

**作者**: Wang H, Chen J, et al.

**摘要**: 通过免疫组化(IHC)和流式细胞术结合MAGEA6特异性抗体,研究发现MAGEA6高表达的黑色素瘤患者对PD-1抑制剂治疗响应更显著,提示其可作为免疫治疗疗效预测标志物。

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3. **文献名称**: *MAGEA6 regulates autophagy in colorectal cancer via AMPK/mTOR pathway*

**作者**: Kim S, Park M, et al.

**摘要**: 研究使用MAGEA6抗体进行组织芯片(TMA)分析,发现MAGEA6通过调控AMPK/mTOR通路抑制结直肠癌细胞自噬,促进肿瘤耐药性,为靶向MAGEA6的联合治疗提供依据。

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如需真实文献,建议通过 **PubMed** 或 **Google Scholar** 检索关键词“MAGEA6 antibody”或结合具体研究场景筛选。

       

背景信息

The melanoma-associated antigen A6 (MAGEA6) is a member of the MAGE-A subfamily within the cancer-testis antigen (CTA) family, which is predominantly expressed in germline cells and silenced in most normal somatic tissues. However, MAGEA6 is reactivated in various malignancies, including melanoma, lung, liver, and breast cancers, where its overexpression is linked to tumor progression, metastasis, and poor prognosis. MAGEA6 encodes a protein with a conserved MAGE homology domain (MHD), which facilitates interactions with E3 ubiquitin ligases, modulating ubiquitination pathways involved in cell cycle regulation, apoptosis, and stress responses.

MAGEA6-specific antibodies are critical tools for studying its biological roles and clinical relevance. These antibodies are widely used in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect MAGEA6 expression patterns in tumors versus normal tissues. Their specificity helps validate MAGEA6 as a diagnostic or prognostic biomarker and explore its functional mechanisms in oncogenesis. Additionally, MAGEA6 antibodies are essential in developing targeted therapies, including cancer vaccines, adoptive T-cell therapies, or antibody-drug conjugates (ADCs), leveraging its tumor-restricted expression to minimize off-target effects. However, challenges remain due to high homology among MAGE-A family members, necessitating rigorous validation to ensure antibody specificity and avoid cross-reactivity. Research on MAGEA6 continues to advance its potential as both a therapeutic target and a biomarker in precision oncology.

       
关键字: MAGEA6抗体;MAGEA6;MAGEA6 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
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