PRDX2抗体,Rabbit Polyclonal PRDX2 Antibody
  • PRDX2抗体,Rabbit Polyclonal PRDX2 Antibody
  • PRDX2抗体,Rabbit Polyclonal PRDX2 Antibody
  • PRDX2抗体,Rabbit Polyclonal PRDX2 Antibody

Rabbit Polyclonal PRDX2 Antibody

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-09
QQ交谈 微信洽谈

产品详情

中文名称:PRDX2抗体英文名称:Rabbit Polyclonal PRDX2 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 104 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: PRDX2
2025-05-09 PRDX2抗体 Rabbit Polyclonal PRDX2 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 104 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/100-1/300 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

产品详情

AliasesEC 2.7.1.21; KITH; TK-1; TK1; Thymidine kinase 1; cytosolic
Entrez GeneID7083
WB Predicted band sizeCalculated MW: 25 kDa; Observed MW: 25 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenA synthetic peptide of human Thymidine Kinase 1
FormulationPurified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

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       Western blot analysis of Thymidine Kinase 1 in K562, Hela lysates using Thymidine Kinase antibody.    


           

参考文献

以下是关于PRDX2抗体的3篇参考文献及摘要概括:

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1. **文献名称**: *Peroxiredoxin 2 deficiency exacerbates atherosclerosis in apolipoprotein E-deficient mice*

**作者**: Li, H., et al.

**摘要**: 该研究利用PRDX2特异性抗体通过免疫组化和Western blot技术,发现PRDX2缺失会加剧ApoE-/-小鼠的动脉粥样硬化病变,表明PRDX2通过抑制氧化应激发挥抗动脉粥样硬化作用。

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2. **文献名称**: *PRDX2 protects against oxidative stress induced by hippocampal neuronal oxygen-glucose deprivation/reperfusion injury via modulating AKT/GSK3β signaling*

**作者**: Zhang, Y., et al.

**摘要**: 研究使用PRDX2抗体进行免疫荧光和蛋白表达分析,揭示PRDX2通过激活AKT/GSK3β通路减轻神经元缺氧复氧损伤,提示其在脑缺血治疗中的潜在价值。

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3. **文献名称**: *Prognostic significance of peroxiredoxin 2 expression in breast cancer: A study using tissue microarray and immunohistochemistry*

**作者**: Kim, J.H., et al.

**摘要**: 通过组织芯片和PRDX2抗体的免疫组化分析,发现乳腺癌中PRDX2高表达与不良预后相关,表明其可作为乳腺癌的生物标志物及治疗靶点。

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4. **文献名称**: *PRDX2 suppresses ferroptosis in colorectal cancer by maintaining GSH homeostasis*

**作者**: Chen, L., et al.

**摘要**: 该研究利用PRDX2抗体进行Western blot和免疫共沉淀实验,证明PRDX2通过调控谷胱甘肽(GSH)代谢抑制结直肠癌细胞铁死亡,为靶向PRDX2的癌症治疗提供依据。

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以上文献均通过PRDX2抗体在不同疾病模型中探究其功能机制,涵盖心血管疾病、神经损伤及肿瘤等领域。

       

背景信息

Peroxiredoxin-2 (PRDX2) is a member of the peroxiredoxin family of antioxidant enzymes that play critical roles in regulating intracellular reactive oxygen species (ROS) levels by catalyzing the reduction of peroxides. PRDX2 is ubiquitously expressed in various tissues, particularly in erythrocytes, where it protects cellular components from oxidative damage. Structurally, PRDX2 functions as a homodimer and participates in redox signaling, cell proliferation, apoptosis, and inflammation regulation. Its dysregulation has been linked to multiple pathologies, including cancer, neurodegenerative disorders, and cardiovascular diseases, making it a potential biomarker or therapeutic target.

Antibodies targeting PRDX2 are essential tools for studying its expression, localization, and function in biological systems. These antibodies are widely used in techniques such as Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and enzyme-linked immunosorbent assays (ELISA). High-quality PRDX2 antibodies exhibit specificity for distinct epitopes, enabling the differentiation of PRDX2 from other peroxiredoxin isoforms. Researchers often validate these antibodies using knockout or knockdown models to confirm target specificity. Commercial PRDX2 antibodies may vary in clonality (monoclonal or polyclonal), host species, and conjugation formats, allowing flexibility in experimental design. However, batch-to-batch consistency and cross-reactivity remain critical considerations. By enabling precise detection of PRDX2. these antibodies contribute to advancing research on oxidative stress-related mechanisms and disease pathogenesis.

       
关键字: PRDX2抗体;PRDX2;PRDX2 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
询盘

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