TOP2A抗体,Rabbit Polyclonal TOP2A Antibody
  • TOP2A抗体,Rabbit Polyclonal TOP2A Antibody
  • TOP2A抗体,Rabbit Polyclonal TOP2A Antibody
  • TOP2A抗体,Rabbit Polyclonal TOP2A Antibody

Rabbit Polyclonal TOP2A Antibody

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-09
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产品详情

中文名称:TOP2A抗体英文名称:Rabbit Polyclonal TOP2A Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 121 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: TOP2A
2025-05-09 TOP2A抗体 Rabbit Polyclonal TOP2A Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 121 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

产品详情

AliasesTOP2; TP2A
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human TOP2A
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P04223(TOP2A Antibody) at dilution 1/30. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P04223(TOP2A Antibody) at dilution 1/30. (Original magnification: ×200)    


           

参考文献

以下是关于TOP2A抗体的3篇参考文献,包含文献名称、作者及摘要概括:

1. **文献名称**:*"TOP2A amplification in breast cancer: a dual-color FISH study on tissue microarrays"*

**作者**:Järvinen TA, Tanner M, Rantanen V, et al.

**摘要**:研究利用TOP2A抗体和荧光原位杂交(FISH)技术分析乳腺癌组织中TOP2A基因的扩增情况,发现其与蒽环类化疗药物敏感性相关,提示TOP2A可作为治疗反应预测标志物。

2. **文献名称**:*"Co-amplification and prognostic value of HER2 and TOP2A in invasive breast cancer"*

**作者**:O'Malley FP, Chia S, Tu D, et al.

**摘要**:通过免疫组化(IHC)和FISH检测乳腺癌样本中HER2与TOP2A的共扩增,发现TOP2A扩增与患者较差的无病生存期相关,并可能影响靶向治疗策略。

3. **文献名称**:*"Topoisomerase IIα as a marker of cell proliferation and prognosis in colorectal cancer"*

**作者**:Alonso-Alconada L, Muinelo-Romay L, Madissoo K, et al.

**摘要**:研究评估TOP2A抗体在结直肠癌组织中的表达水平,证实其高表达与细胞增殖活性升高及患者预后不良相关,提示其在肿瘤进展中的关键作用。

以上文献均聚焦于TOP2A抗体在癌症诊断、治疗预测及预后评估中的应用。

       

背景信息

TOP2A (DNA topoisomerase II alpha) is a nuclear enzyme critical for DNA replication, transcription, and chromosome segregation by regulating DNA topology during cell division. The TOP2A gene encodes this enzyme, which is highly expressed in proliferating cells, particularly during the G2/M phase of the cell cycle. Dysregulation of TOP2A is implicated in cancer development, as its overexpression or genetic alterations (e.g., amplifications, deletions) are linked to tumor aggressiveness, genomic instability, and therapeutic resistance.

Antibodies targeting TOP2A are widely used in research and diagnostics to assess protein expression levels in tissues, often via immunohistochemistry (IHC). In clinical settings, TOP2A status is evaluated alongside HER2 in breast cancer to guide treatment decisions, as TOP2A co-amplification with HER2 may predict sensitivity to anthracycline-based chemotherapy. Additionally, TOP2A antibodies help study drug mechanisms, such as the action of topoisomerase inhibitors (e.g., etoposide, doxorubicin), which trap TOP2A-DNA complexes to induce lethal DNA breaks. However, TOP2A testing remains controversial due to variability in antibody performance, assay standardization challenges, and conflicting evidence regarding its standalone prognostic value. Despite this, it remains a biomarker of interest in oncology for understanding cell proliferation dynamics and optimizing targeted therapies.

       
关键字: TOP2A抗体;TOP2A;TOP2A Antibody;

公司简介

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成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
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