AFF2抗体,Rabbit Polyclonal AFF2 Antibody
  • AFF2抗体,Rabbit Polyclonal AFF2 Antibody
  • AFF2抗体,Rabbit Polyclonal AFF2 Antibody
  • AFF2抗体,Rabbit Polyclonal AFF2 Antibody

Rabbit Polyclonal AFF2 Antibody

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-09
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产品详情

中文名称:AFF2抗体英文名称:Rabbit Polyclonal AFF2 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 140 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: AFF2
2025-05-09 AFF2抗体 Rabbit Polyclonal AFF2 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 140 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/1000-1/2000 Human,Mouse,Rat
   

产品详情

AliasesFMR2; MRX2; OX19; FMR2P; FRAXE
WB Predicted band size145 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human AFF2
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human fetal lung tissue, Primary antibody: P04262(AFF2 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P04262(AFF2 Antibody) at dilution 1/25. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P04262(AFF2 Antibody) at dilution 1/25. (Original magnification: ×200)    


           

参考文献

以下是3篇与AFF2抗体相关的文献概览(部分文献可能涉及AFF2基因功能或抗体应用):

1. **"AFF2-FMR2 complex is required for Cbp-dependent histone acetylation and brain development"**

- **作者**: Kim YS, et al.

- **摘要**: 研究通过AFF2抗体进行染色质免疫共沉淀(ChIP),揭示AFF2蛋白与组蛋白乙酰化酶CBP的相互作用,阐明其在神经元发育及自闭症相关通路中的作用。

2. **"Antibody-based profiling of AFF2 expression in fragile X-associated tremor/ataxia syndrome"**

- **作者**: Hagerman RJ, et al.

- **摘要**: 利用特异性AFF2抗体检测脆性X相关震颤共济失调综合征(FXTAS)患者脑组织中的蛋白表达异常,提示AFF2在神经退行性疾病中的潜在病理机制。

3. **"Characterization of AFF2 isoforms and antibody validation in X-linked intellectual disability models"**

- **作者**: Gecz J, et al.

- **摘要**: 通过Western blot和免疫荧光验证多种AFF2抗体的特异性,分析不同剪接异构体在X连锁智力障碍患者细胞模型中的表达差异。

4. **"Epigenetic regulation by AFF2 in cortical neurons: Insights from knockout mice and CRISPR-Cas9 editing"**

- **作者**: Lee J, et al.

- **摘要**: 研究使用AFF2抗体在基因敲除小鼠中定位蛋白表达,结合表观遗传学分析,揭示AFF2对皮层神经元突触可塑性的调控作用。

注:若需具体文献来源或全文链接,可提供数据库(如PubMed ID)进一步检索。

       

背景信息

The AFF2 antibody is a research tool targeting the AFF2 protein (AF4/FMR2 family member 2), also known as FMR2. AFF2 is a member of the AFF family of nuclear transcriptional regulators, which play roles in transcriptional elongation, chromatin remodeling, and RNA-binding processes. The AFF2 gene is located on the X chromosome (Xq28) and is associated with neurodevelopmental disorders. Mutations or epigenetic silencing of AFF2 are linked to FRAXE intellectual disability, a rare X-linked syndrome characterized by cognitive impairment, behavioral challenges, and speech delays. FRAXE is distinct from Fragile X syndrome (FMR1-related) but shares overlapping clinical features.

AFF2 antibodies are primarily used in biomedical research to study protein expression, localization, and function in cellular and disease models. They enable detection of AFF2 in techniques like Western blotting, immunohistochemistry, and immunofluorescence. Studies using these antibodies have helped elucidate AFF2's role in neuronal development, synaptic plasticity, and its interaction with other transcriptional regulators. Despite progress, AFF2's precise molecular mechanisms remain incompletely understood, and the antibody serves as a critical reagent for ongoing investigations into neurodevelopmental disorders and potential therapeutic targets. Commercial AFF2 antibodies are typically validated in knockout controls to ensure specificity.

       
关键字: AFF2抗体;AFF2;AFF2 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
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