MAP3K2抗体,Rabbit Polyclonal MAP3K2 Antibody
  • MAP3K2抗体,Rabbit Polyclonal MAP3K2 Antibody
  • MAP3K2抗体,Rabbit Polyclonal MAP3K2 Antibody
  • MAP3K2抗体,Rabbit Polyclonal MAP3K2 Antibody

MAP3K2抗体 新品

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-09
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产品详情

中文名称:MAP3K2抗体英文名称:Rabbit Polyclonal MAP3K2 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 161 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: MAP3K2
2025-05-09 MAP3K2抗体 Rabbit Polyclonal MAP3K2 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 161 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/1000-1/2000 Human,Mouse,Rat
   

产品详情

AliasesMEKK2; MEKK2B
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human MAP3K2
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P04312(MAP3K2 Antibody) at dilution 1/15. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P04312(MAP3K2 Antibody) at dilution 1/15. (Original magnification: ×200)    


           

参考文献

以下是3篇关于MAP3K2抗体的相关文献摘要(示例为模拟生成,非真实文献):

1. **文献名称**:*MAP3K2 regulates RAS-driven lung cancer growth through kinase-dependent and -independent pathways*

**作者**:Zhang Y, et al.

**摘要**:研究利用MAP3K2特异性抗体进行免疫共沉淀实验,揭示MAP3K2通过磷酸化下游靶点及支架蛋白相互作用,促进KRAS突变肺癌细胞的增殖和转移。

2. **文献名称**:*Antibody-based profiling of MAP3K2 in hepatocellular carcinoma reveals its prognostic significance*

**作者**:Li H, Wang X.

**摘要**:通过Western blot和免疫组化验证商业化MAP3K2抗体的特异性,发现MAP3K2在肝癌组织中高表达,且与患者生存率负相关,提示其作为治疗靶点的潜力。

3. **文献名称**:*MAP3K2 controls T cell differentiation via JNK/c-Jun signaling*

**作者**:Smith J, et al.

**摘要**:研究使用CRISPR敲除结合MAP3K2抗体阻断实验,证明MAP3K2通过调控JNK通路影响Th17细胞分化,为自身免疫疾病机制提供新见解。

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注:以上内容为示例,实际文献需通过PubMed/Google Scholar检索关键词“MAP3K2 antibody”或“MAP3K2 function”获取。真实文献可能侧重抗体开发(如《*Monoclonal antibody generation against human MAP3K2*》)或疾病机制研究。

       

背景信息

The MAP3K2 antibody is a crucial tool for studying the mitogen-activated protein kinase kinase kinase 2 (MAP3K2), a serine/threonine kinase within the MAPK signaling cascade. MAP3K2. also known as MEKK2. plays a pivotal role in regulating cellular responses such as proliferation, differentiation, apoptosis, and stress signaling. It activates downstream MAPK pathways (e.g., JNK, ERK, p38) by phosphorylating MAP2Ks, often in response to extracellular stimuli like cytokines, growth factors, or environmental stress. Dysregulation of MAP3K2 is implicated in cancer, inflammatory diseases, and developmental disorders, making it a therapeutic target of interest.

Antibodies targeting MAP3K2 enable researchers to detect and quantify its expression, phosphorylation status, and interactions in various experimental models. These antibodies are widely used in techniques including Western blotting, immunohistochemistry, immunofluorescence, and co-immunoprecipitation. Specific isoforms or phosphorylated forms of MAP3K2 can be identified using phosphorylation-specific antibodies, aiding in the study of pathway activation dynamics. Additionally, MAP3K2 inhibitors are being explored in preclinical studies, and corresponding antibodies help assess drug efficacy by monitoring pathway inhibition. Research has highlighted its role in RAS-driven tumors, immune cell signaling, and epithelial-mesenchymal transition (EMT), underscoring its relevance in both basic and translational biomedical research.

       
关键字: MAP3K2抗体;MAP3K2;MAP3K2 Antibody;

公司简介

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成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
普通会员
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
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