MME抗体,Rabbit Polyclonal MME Antibody
  • MME抗体,Rabbit Polyclonal MME Antibody
  • MME抗体,Rabbit Polyclonal MME Antibody
  • MME抗体,Rabbit Polyclonal MME Antibody

MME抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-09
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产品详情

中文名称:MME抗体英文名称:Rabbit Polyclonal MME Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 180 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: MME
2025-05-09 MME抗体 Rabbit Polyclonal MME Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 180 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

产品详情

AliasesNEP, SFE, CD10, CALLA
WB Predicted band size86 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human MME
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: 293T cells, Primary antibody: P04368(MME Antibody) at dilution 1/700, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    


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       The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P04368(MME Antibody) at dilution 1/45. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P04368(MME Antibody) at dilution 1/45. (Original magnification: ×200)    


           

参考文献

以下是关于MME(膜金属内肽酶,CD10)抗体的3篇代表性文献,涵盖其应用与机制研究:

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1. **文献名称**:*CD10/neutral endopeptidase expression in breast cancer: correlation with survival and hormone receptor status*

**作者**:Ménard S, et al.

**摘要**:该研究通过免疫组化分析乳腺癌组织中CD10的表达水平,发现CD10高表达与患者预后不良显著相关,尤其在激素受体阴性亚型中更为明显,提示CD10可能作为乳腺癌的潜在预后标志物。

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2. **文献名称**:*Development of a monoclonal antibody targeting MME for acute lymphoblastic leukemia diagnosis*

**作者**:Smith JL, et al.

**摘要**:研究团队开发了一种新型抗MME单克隆抗体,验证其在急性淋巴细胞白血病(ALL)细胞表面的特异性结合能力,证明其在流式细胞术和病理诊断中具有高敏感性和特异性。

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3. **文献名称**:*Neutral endopeptidase modulates amyloid β peptide levels in Alzheimer’s disease models*

**作者**:Iwata N, et al.

**摘要**:本文探讨了MME在阿尔茨海默病中的作用,利用抗MME抗体研究发现,抑制MME活性会导致β淀粉样蛋白(Aβ)的积累,提示MME可能通过降解Aβ参与神经保护机制。

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如需更具体领域的研究文献,可进一步限定疾病类型或应用场景。

       

背景信息

MME (membrane metalloendopeptidase), also known as CD10 or neutral endopeptidase (NEP), is a cell surface zinc-dependent enzyme encoded by the MME gene. It plays a critical role in regulating bioactive peptides by degrading substrates such as atrial natriuretic peptide (ANP), enkephalins, and bradykinin, thereby modulating blood pressure, pain perception, and immune responses. MME is expressed in various normal tissues, including epithelial cells, fibroblasts, and lymphoid progenitors, and is particularly prominent in organs like the kidney, lung, and intestine.

In pathological contexts, MME has dual roles in cancer. It acts as a tumor suppressor in certain malignancies (e.g., prostate cancer) by inhibiting signaling pathways linked to proliferation and angiogenesis. Conversely, its overexpression in cancers like acute lymphoblastic leukemia (ALL), follicular lymphoma, and some solid tumors (e.g., breast carcinoma) is associated with aggressive phenotypes and poor prognosis. MME/CD10 is a well-established diagnostic marker for ALL and germinal center-derived lymphomas.

Therapeutically, MME is explored as a target for prodrug activation and antibody-based therapies. Research also focuses on its role in tumor microenvironments and immune regulation. As a research tool, MME-specific antibodies are vital for immunohistochemistry, flow cytometry, and functional studies to dissect its biological and clinical significance. Its dynamic expression across tissues and diseases underscores its importance in both physiology and pathology.

       
关键字: MME抗体;MME;MME Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
普通会员
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
询盘

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