SLC32A1抗体

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     Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Mouse brain tissue, Primary antibody: P04459(SLC32A1 Antibody) at dilution 1/950, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds    

  
  

SLC32A1. also known as vesicular inhibitory amino acid transporter (VIAAT) or vesicular GABA transporter (VGAT), is a transmembrane protein responsible for transporting gamma-aminobutyric acid (GABA) and glycine into synaptic vesicles within inhibitory neurons. As a member of the solute carrier family, it plays a critical role in regulating inhibitory neurotransmission by ensuring the proper storage and release of these neurotransmitters. Antibodies targeting SLC32A1 are widely used in neuroscience research to identify and study GABAergic and glycinergic neurons, map inhibitory circuits, and investigate disorders linked to inhibitory signaling dysfunction, such as epilepsy, anxiety, and schizophrenia.

These antibodies are commonly applied in techniques like immunohistochemistry, immunofluorescence, and Western blotting to visualize SLC32A1 expression in brain tissues or cultured neurons. They typically recognize specific epitopes, such as cytoplasmic or extracellular domains, aiding in subcellular localization studies. Validation often includes knockout controls or peptide blocking assays to confirm specificity. Recent studies also utilize SLC32A1 antibodies to explore neurodevelopmental changes, synaptic plasticity, and the effects of pharmacological agents on inhibitory pathways. Their utility in distinguishing inhibitory from excitatory neuronal populations makes them indispensable tools for understanding the balance of neural network activity.