PIK3R3抗体,Rabbit Polyclonal PIK3R3 Antibody
  • PIK3R3抗体,Rabbit Polyclonal PIK3R3 Antibody
  • PIK3R3抗体,Rabbit Polyclonal PIK3R3 Antibody
  • PIK3R3抗体,Rabbit Polyclonal PIK3R3 Antibody

PIK3R3抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-09
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产品详情

中文名称:PIK3R3抗体英文名称:Rabbit Polyclonal PIK3R3 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 278 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: PIK3R3
2025-05-09 PIK3R3抗体 Rabbit Polyclonal PIK3R3 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 278 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

产品详情

Aliases30K, CANP, CDPS, CSS1, CANPS, CAPN4, CALPAIN4
WB Predicted band size28 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human CAPNS1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 12%SDS-PAGE, Lysate: 60 μg, Lane 1-2: K562 cells, NIH/3T3 cells, Primary antibody: P07142(CAPNS1 Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 15 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P07142(CAPNS1 Antibody) at dilution 1/60. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human brain tissue using P07142(CAPNS1 Antibody) at dilution 1/60. (Original magnification: ×200)    


           

参考文献

以下是3篇与PIK3R3抗体相关的文献示例(内容为虚构,供参考格式):

1. **文献名称**:*PIK3R3 regulates ovarian cancer progression via AKT signaling*

**作者**:Chen L, et al.

**摘要**:研究通过Western blot和免疫组化使用PIK3R3抗体,发现其在卵巢癌中高表达,并通过激活AKT通路促进肿瘤侵袭转移。

2. **文献名称**:*Role of PIK3R3 in hepatocellular carcinoma tumorigenesis*

**作者**:Wang Y, et al.

**摘要**:利用PIK3R3特异性抗体进行组织芯片分析,证实其表达与肝癌患者预后不良相关,并调控mTOR信号通路。

3. **文献名称**:*PIK3R3 antibody-based detection in colorectal cancer diagnostics*

**作者**:Kim S, et al.

**摘要**:开发了一种高灵敏度的PIK3R3单克隆抗体,用于ELISA检测结直肠癌患者血清中PIK3R3水平,显示其作为生物标志物的潜力。

4. **文献名称**:*PIK3R3 interacts with TP53 in gastric cancer*

**作者**:Zhang R, et al.

**摘要**:通过免疫共沉淀(Co-IP)结合PIK3R3抗体,揭示其与TP53蛋白的相互作用,影响胃癌细胞凋亡抵抗机制。

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**注**:以上为模拟内容,实际文献需通过PubMed、Google Scholar等平台以关键词“PIK3R3 antibody”或“PIK3R3 function”检索。建议结合具体研究场景筛选抗体应用(如WB、IHC、IP等)或疾病机制相关文献。

       

背景信息

The PIK3R3 antibody targets the phosphoinositide-3-kinase regulatory subunit 3 (PIK3R3), a regulatory component of the class IA phosphatidylinositol 3-kinase (PI3K) family. PI3Ks are lipid kinases critical for intracellular signaling, regulating processes like cell growth, survival, metabolism, and motility. PIK3R3. also known as p55γ, binds to the p110γ catalytic subunit to form the PI3Kγ complex, which is predominantly expressed in immune cells and plays a role in inflammatory responses and immune regulation. Unlike other regulatory subunits (e.g., PIK3R1/R2), PIK3R3 has unique structural features, including a shorter N-terminal domain, which may influence its functional specificity.

Antibodies against PIK3R3 are widely used in research to study its expression, localization, and interaction partners in normal and diseased tissues. They are essential tools for techniques like Western blotting, immunohistochemistry, and co-immunoprecipitation. Dysregulation of PIK3R3 has been implicated in cancer, inflammation, and metabolic disorders, with studies linking its overexpression to tumor progression, drug resistance, and altered PI3K/AKT/mTOR signaling. Commercially available PIK3R3 antibodies are typically developed in rabbits or mice, validated for specificity through knockdown/knockout controls. Researchers rely on these reagents to explore PIK3R3's role as a potential therapeutic target or biomarker, though challenges remain in distinguishing isoforms and ensuring cross-reactivity across species.

       
关键字: PIK3R3抗体;PIK3R3;PIK3R3 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
询盘

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