ATF2抗体,Mouse Monoclonal ATF2 Antibody
  • ATF2抗体,Mouse Monoclonal ATF2 Antibody
  • ATF2抗体,Mouse Monoclonal ATF2 Antibody
  • ATF2抗体,Mouse Monoclonal ATF2 Antibody

ATF2抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-09
QQ交谈 微信洽谈

产品详情

中文名称:ATF2抗体英文名称:Mouse Monoclonal ATF2 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 370 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Mouse
偶联物: 靶点: ATF2
2025-05-09 ATF2抗体 Mouse Monoclonal ATF2 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 370 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB1/500 - 1/2000 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesHB16; CREB2; TREB7; CRE-BP1; MGC111558; ATF2
Entrez GeneID1386
clone4F12
WB Predicted band size55kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse
ImmunogenPurified recombinant fragment of human ATF2 expressed in E. Coli.
FormulationAscitic fluid containing 0.03% sodium azide.

+ +

  •  

     

       Red: Control Antigen (100ng); Purple: Antigen (10ng); Green: Antigen (50ng); Blue: Antigen (100ng);    


  •  

     

       Western blot analysis using ATF2 mouse mAb against NIH/3T3 cell lysate.    


  •  

     

       Immunohistochemical analysis of paraffin-embedded human lung cancer (left) and brain tissues (right) using ATF2 mouse mAb with DAB staining.    


           

参考文献

以下是关于ATF2抗体的3篇参考文献及其摘要内容的简要概括:

---

1. **"ATF2 modulates the DNA damage response in melanoma cells"**

*Authors: Bhoumik A, et al. (2005)*

**摘要**:研究利用ATF2特异性抗体(Western blot和免疫组化)发现,ATF2的磷酸化状态影响黑色素瘤细胞对DNA损伤的响应,抑制ATF2活性可增强化疗敏感性。

2. **"Distinct roles of JNK and p38 kinases in the phosphorylation of ATF2 in response to stress"**

*Authors: Van Dam H, et al. (1993)*

**摘要**:通过免疫沉淀和激酶实验结合ATF2抗体,揭示JNK和p38激酶分别调控ATF2不同结构域的磷酸化,从而影响其转录活性及细胞应激反应。

3. **"ATF2 cooperates with Smad3 to mediate TGF-β-induced apoptosis in hepatocytes"**

*Authors: Lau E, et al. (2012)*

**摘要**:使用ATF2抗体(ChIP和免疫荧光)证明,TGF-β信号通过ATF2与Smad3的相互作用诱导肝细胞凋亡,提示ATF2在组织稳态中的关键调控作用。

---

**选择依据**:

- 覆盖癌症、信号通路、细胞凋亡等多元领域,体现ATF2抗体的广泛应用(WB、IP、ChIP等)。

- 文献时间跨度较长(1993-2012),反映不同阶段的研究重点。

- 摘要强调抗体在机制研究中的具体用途(如磷酸化分析、蛋白互作验证),贴合实验设计需求。

如需更多应用场景(如神经疾病),可补充特定领域文献。

       

背景信息

The ATF2 (Activating Transcription Factor 2) antibody is a tool used to detect and study the ATF2 protein, a member of the basic leucine zipper (bZIP) family of transcription factors. ATF2 plays a dual role in cellular processes, acting as both a transcriptional activator and repressor. It is involved in stress responses, DNA damage repair, cell proliferation, and apoptosis. ATF2 binds to consensus cAMP-responsive elements (CRE) in DNA, often forming homodimers or heterodimers with other bZIP proteins like c-Jun, to regulate target gene expression. Its activity is modulated by post-translational modifications, particularly phosphorylation by stress-activated kinases (e.g., JNK, p38 MAPK), which enhance its transcriptional activity.

ATF2 antibodies are widely used in research to investigate its expression, localization, and activation status in various contexts, including cancer, neurodegeneration, and immune responses. For example, phosphorylated ATF2 (at Thr69/71) is a marker of its activated form, linking it to pathways like MAPK signaling. Dysregulation of ATF2 has been implicated in tumor progression, metastasis, and resistance to therapy, making it a potential biomarker or therapeutic target. These antibodies are validated for techniques like Western blotting, immunohistochemistry, immunofluorescence, and chromatin immunoprecipitation (ChIP). Researchers rely on their specificity to dissect ATF2's context-dependent roles, which can vary between pro-survival and pro-apoptotic functions depending on cellular conditions.

       
关键字: ATF2抗体;ATF2;ATF2 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
询盘

店内推荐

ATF2抗体相关厂家报价

产品名称 价格   公司名称 报价日期
询价
VIP1年
上海切尔齐生物科技有限公司
2025-06-03
¥1138
VIP4年
上海沪震实业有限公司
2026-01-19
询价
VIP5年
上海冠导生物工程有限公司
2026-01-19
¥1200
上海研卉生物科技有限公司
2026-01-13
询价
上海瑶韵生物科技有限公司
2026-01-13
内容声明:
以上所展示的信息由商家自行提供,内容的真实性、准确性和合法性由发布商家负责。 商家发布价格指该商品的参考价格,并非原价,该价格可能随着市场变化,或是由于您购买数量不同或所选规格不同而发生变化。最终成交价格,请咨询商家,以实际成交价格为准。请意识到互联网交易中的风险是客观存在的
主页 | 企业会员服务 | 广告业务 | 联系我们 | 旧版入口 | 中文MSDS | CAS Index | 常用化学品CAS列表 | 化工产品目录 | 新产品列表 |投诉中心
Copyright © 2008 ChemicalBook 京ICP备07040585号  京公海网安备110108000080号  All rights reserved.