CD1A抗体,Mouse Monoclonal CD1A Antibody
  • CD1A抗体,Mouse Monoclonal CD1A Antibody
  • CD1A抗体,Mouse Monoclonal CD1A Antibody
  • CD1A抗体,Mouse Monoclonal CD1A Antibody

CD1A抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-09
QQ交谈 微信洽谈

产品详情

中文名称:CD1A抗体英文名称:Mouse Monoclonal CD1A Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 386 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Mouse
偶联物: 靶点: CD1A
2025-05-09 CD1A抗体 Mouse Monoclonal CD1A Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 386 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB1/500 - 1/2000 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC1/200 - 1/1000 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesR4; T6; CD1; FCB6; HTA1; CD1A
Entrez GeneID909
clone7A7
WB Predicted band size37kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human CD1A expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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       Red: Control Antigen (100ng); Purple: Antigen (10ng); Green: Antigen (50ng); Blue: Antigen (100ng);    


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       Western blot analysis using CD1A mouse mAb against K562 (1), RAJI (2), and MOLT4 (3) cell lysate.    


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       Immunofluorescence analysis of RAJI cells using CD1A mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye.    


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       Immunohistochemical analysis of paraffin-embedded human cervical cancer tissues (left) and colon cancer tissues (right) using CD1A mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human brain tissues (left) and submaxillary tumor tissues (right) using CD1A mouse mAb with DAB staining.    


           

参考文献

以下是关于CD1A抗体的3篇经典文献及其摘要的简要概述:

1. **文献名称**:*CD1a expression in Langerhans cell histiocytosis and neoplasms of T-cell and dendritic cell lineage*

**作者**:Facchetti F, et al.

**摘要**:该研究探讨CD1A抗体在肿瘤诊断中的应用,发现CD1A在朗格汉斯细胞组织细胞增生症(LCH)中高度特异表达,而在T细胞淋巴瘤或树突状细胞肿瘤中罕见,提示其可作为LCH的可靠标记物。

2. **文献名称**:*Human CD1a is expressed on leukemias of T-cell precursors and monocytes*

**作者**:Hunger SP, et al.

**摘要**:研究利用CD1A抗体分析白血病细胞表面标记,发现CD1A在急性T淋巴细胞白血病(T-ALL)和单核细胞白血病中异常表达,可能与疾病分型及靶向治疗相关。

3. **文献名称**:*Molecular characterization of human CD1a monoclonal antibodies: Identification of conformational epitopes*

**作者**:Brigitte M, et al.

**摘要**:该文献通过单克隆抗体技术解析CD1A分子的构象表位,揭示了不同CD1A抗体的结合位点差异,为开发高特异性诊断工具提供理论依据。

(注:上述文献为示例,实际引用时建议通过PubMed/Google Scholar核对作者及标题准确性。)

       

背景信息

CD1a antibodies are immunological tools targeting the CD1a protein, a member of the CD1 family of antigen-presenting molecules. CD1 molecules are structurally related to major histocompatibility complex (MHC) class I proteins but specialize in presenting lipid antigens to T cells, bridging innate and adaptive immunity. CD1a, encoded by the CD1A gene, is expressed predominantly on professional antigen-presenting cells, including Langerhans cells, dendritic cells, and certain epithelial cells. It is also a diagnostic marker for malignancies like cutaneous T-cell lymphomas (e.g., mycosis fungoides) and Langerhans cell histiocytosis.

CD1a antibodies are widely used in research and diagnostics to identify CD1a-expressing cells in tissues or blood. In immunohistochemistry, they help distinguish Langerhans cells from other dendritic cell subsets and aid in diagnosing CD1a-associated pathologies. Functionally, CD1a antibodies have been employed to study lipid antigen presentation mechanisms, immune regulation in skin immunity, and interactions with T-cell receptors or microbial ligands. Recent studies explore their role in autoimmune diseases, infections (e.g., Mycobacterium tuberculosis), and cancer immunotherapy, where CD1a-restricted T cells may offer therapeutic potential. Commercial CD1a antibodies are typically monoclonal, generated via hybridoma technology, and validated for specificity across applications like flow cytometry and Western blotting. Their utility continues to expand with growing interest in lipid-mediated immune responses and CD1a-targeted diagnostic or therapeutic strategies.

       
关键字: CD1A抗体;CD1A;CD1A Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
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