LPA抗体,Mouse Monoclonal LPA Antibody
  • LPA抗体,Mouse Monoclonal LPA Antibody
  • LPA抗体,Mouse Monoclonal LPA Antibody
  • LPA抗体,Mouse Monoclonal LPA Antibody

LPA抗体 新品

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-10
QQ交谈 微信洽谈

产品详情

中文名称:LPA抗体英文名称:Mouse Monoclonal LPA Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 525 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Mouse
偶联物: 靶点: LPA
2025-05-10 LPA抗体 Mouse Monoclonal LPA Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 525 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC1/200 - 1/1000 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesLP; AK38; APOA
Entrez GeneID4018
clone4H1
WB Predicted band size501kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human LPA (AA: 1823-2013) expressed in E. Coli.  

FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);    


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       Immunofluorescence analysis of HepG2 cells using LPA mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.    


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       Immunohistochemical analysis of paraffin-embedded human liver cancer tissues using LPA mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human breast cancer tissues using LPA mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human rectum cancer tissues using LPA mouse mAb with DAB staining.    


           

参考文献

以下是关于LPA抗体的3篇示例文献(注:内容为虚构示例,仅供参考格式):

1. **文献名称**:*"Therapeutic Targeting of Lipoprotein(a) with Monoclonal Antibodies in Cardiovascular Disease"*

**作者**:Tsimikas S, Stroes ESG

**摘要**:研究探讨了针对脂蛋白(a) [Lp(a)]的单克隆抗体在降低血浆Lp(a)水平及减少动脉粥样硬化斑块形成中的作用,显示其可能成为心血管疾病的新型治疗策略。

2. **文献名称**:*"Anti-LPA Antibody Attenuates Tumor Progression by Blocking Lysophosphatidic Acid Signaling"*

**作者**:Zhang G, Xu Y

**摘要**:通过抑制LPA与受体的结合,该抗体显著降低了多种癌症模型中肿瘤细胞的迁移和侵袭,提示LPA信号通路在癌症转移中的关键作用及抗体治疗的潜力。

3. **文献名称**:*"Development of a Humanized Anti-LPA Antibody for Fibrotic Disease Intervention"*

**作者**:Ohta M, Fujita T

**摘要**:研究报道了一种人源化抗LPA抗体的开发,其在小鼠肺纤维化模型中有效减轻胶原沉积和炎症反应,为纤维化疾病提供了新的治疗方向。

4. **文献名称**:*"Neutralizing LPA Antibody Reduces Vascular Inflammation in Hyperlipidemic Mice"*

**作者**:Lee JH, Kim HK

**摘要**:通过中和LPA活性,该抗体显著降低了高脂血症模型中的血管内皮炎症和氧化应激,表明其在代谢相关血管病变中的保护作用。

如需真实文献,建议通过PubMed或Google Scholar检索关键词“LPA antibody”“Lipoprotein(a) antibody”或“Lysophosphatidic acid antibody”。

       

背景信息

Lipoprotein(a) [Lp(a)] antibodies are immunological tools designed to target and study Lp(a), a unique lipoprotein particle associated with cardiovascular disease risk. Lp(a) consists of a low-density lipoprotein (LDL)-like core linked to apolipoprotein(a) [apo(a)], a glycoprotein homologous to plasminogen. Elevated Lp(a) levels are recognized as an independent risk factor for atherosclerosis, thrombosis, and aortic valve stenosis due to its pro-atherogenic and pro-thrombotic properties.

Lp(a)-specific antibodies play a critical role in research and diagnostics. They enable quantitative measurement of Lp(a) in clinical assays, distinguishing it from LDL by targeting apo(a)'s distinctive kringle IV type 2 repeats. Therapeutic antibodies targeting Lp(a) are also under investigation to mitigate cardiovascular risk. For example, monoclonal antibodies and antisense oligonucleotides aim to reduce Lp(a) synthesis or enhance its clearance. Pelacarsen, an antisense therapy in clinical trials, uses antibody-guided mechanisms to lower Lp(a) levels.

Research on Lp(a) antibodies continues to advance understanding of its pathophysiological roles and therapeutic potential. Their development addresses the unmet need for targeted therapies in individuals with genetically elevated Lp(a), offering promise for personalized cardiovascular risk management.

       
关键字: LPA抗体;LPA;LPA Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (3年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
普通会员
  • 公司成立:3年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
询盘

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