PIK3R1抗体

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P05625(APH1A Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

The PIK3R1 gene encodes the regulatory subunit p85α of phosphatidylinositol 3-kinase (PI3K), a critical signaling enzyme involved in cell growth, survival, metabolism, and apoptosis. As a regulatory component, p85α stabilizes the catalytic subunit (p110) of PI3K and modulates its lipid kinase activity. PIK3R1 antibodies are essential tools for studying the expression, localization, and functional interactions of this protein in physiological and pathological contexts. These antibodies are widely used in techniques such as Western blotting, immunohistochemistry (IHC), and immunoprecipitation (IP) to assess protein levels, tissue distribution, and molecular pathways in cancer, metabolic disorders, and immune diseases.

Mutations in PIK3R1 are linked to diseases including primary immunodeficiency, insulin resistance, and cancers. Researchers employ PIK3R1 antibodies to investigate how dysregulated PI3K signaling contributes to tumorigenesis, therapy resistance, or metabolic dysfunction. For example, altered p85α expression or activity has been observed in breast, ovarian, and colorectal cancers, making these antibodies valuable for mechanistic studies and biomarker validation. Commercially available PIK3R1 antibodies vary in specificity, with validation often performed using knockout cell lines or tissues to confirm target recognition. Challenges include cross-reactivity with other PI3K regulatory isoforms (e.g., p85β) and distinguishing post-translational modifications. Despite these limitations, PIK3R1 antibodies remain indispensable for unraveling the complex roles of PI3K signaling in health and disease.