UTF1抗体,Mouse Monoclonal UTF1 Antibody
  • UTF1抗体,Mouse Monoclonal UTF1 Antibody
  • UTF1抗体,Mouse Monoclonal UTF1 Antibody
  • UTF1抗体,Mouse Monoclonal UTF1 Antibody

UTF1抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-10
QQ交谈 微信洽谈

产品详情

中文名称:UTF1抗体英文名称:Mouse Monoclonal UTF1 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 557 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Mouse
偶联物: 靶点: UTF1
2025-05-10 UTF1抗体 Mouse Monoclonal UTF1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 557 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC咨询技术 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

Entrez GeneID8433
clone5B6
WB Predicted band size36.4kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human UTF1 (AA: 148-214) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

+ +

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       Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);    


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       Flow cytometric analysis of K562 cells using UTF1 mouse mAb (green) and negative control (purple).    


           

参考文献

以下是关于UTF1抗体的3篇参考文献示例(文献信息为虚构,仅供格式参考):

1. **文献名称**: "UTF1 maintains pluripotency by regulating chromatin accessibility in embryonic stem cells"

**作者**: Kristensen DM et al.

**摘要**: 研究利用UTF1抗体进行ChIP-seq分析,发现UTF1通过调控染色质开放状态维持胚胎干细胞多能性,与PRC2复合体协同抑制分化基因。

2. **文献名称**: "UTF1 as a novel biomarker for germ cell tumors: immunohistochemical validation"

**作者**: Nettersheim D et al.

**摘要**: 通过免疫组化验证UTF1抗体在生殖细胞肿瘤中的特异性表达,证明其可作为精原细胞瘤和胚胎癌的可靠诊断标志物。

3. **文献名称**: "Dynamic expression of UTF1 during somatic cell reprogramming revealed by monoclonal antibody analysis"

**作者**: Okashita N, Kiso M et al.

**摘要**: 开发新型抗UTF1单克隆抗体,揭示其在体细胞重编程早期阶段动态表达模式,提示其在诱导多能性中的调控功能。

注:实际文献需通过PubMed/Web of Science等平台检索,建议使用关键词"UTF1 antibody"+"application"或结合具体研究领域筛选。

       

背景信息

The UTF1 (Undifferentiated Embryonic Cell Transcription Factor 1) antibody is a tool used to study the UTF1 protein, a transcription regulator highly expressed in embryonic stem cells (ESCs) and germ cells. UTF1 belongs to the PUFF (PGC/ESC-specific UTF-1 Associated Factor) family and plays a role in chromatin remodeling, transcriptional regulation, and maintaining pluripotency. It interacts with key pluripotency factors like Oct4. Sox2. and Nanog, and is implicated in modulating gene silencing and chromatin dynamics during early development. UTF1 expression decreases upon differentiation, suggesting its role in preserving the undifferentiated state of stem cells.

The UTF1 antibody is widely used in techniques such as chromatin immunoprecipitation (ChIP), immunofluorescence (IF), and Western blotting (WB) to investigate pluripotency mechanisms, epigenetic regulation, and cellular reprogramming. It helps identify UTF1 binding sites on DNA, revealing its involvement in repressing developmental genes in ESCs. Studies also link UTF1 to Polycomb repressive complexes, highlighting its role in histone modification (e.g., H2AK119ub1) and gene silencing.

Additionally, UTF1 antibodies are utilized in cancer research, as UTF1 is abnormally expressed in certain tumors, potentially influencing oncogenesis. Researchers rely on its specificity for human, mouse, or other species to explore UTF1's dual role in stem cell biology and disease contexts. Its application advances understanding of early development, epigenetic landscapes, and regenerative medicine strategies.

       
关键字: UTF1抗体;UTF1;UTF1 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
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