DKK3抗体,Mouse Monoclonal DKK3 Antibody
  • DKK3抗体,Mouse Monoclonal DKK3 Antibody
  • DKK3抗体,Mouse Monoclonal DKK3 Antibody
  • DKK3抗体,Mouse Monoclonal DKK3 Antibody

DKK3抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-10
QQ交谈 微信洽谈

产品详情

中文名称:DKK3抗体英文名称:Mouse Monoclonal DKK3 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 569 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Mouse
偶联物: 靶点: DKK3
2025-05-10 DKK3抗体 Mouse Monoclonal DKK3 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 569 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB1/500-1/1000 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesRIG; REIC
Entrez GeneID27122
clone8A5C6
WB Predicted band size38.3kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat,Rabbit,Monkey
ImmunogenPurified recombinant fragment of human DKK3 (AA: 91-350 ) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);    


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       Western blot analysis using Desmin mouse mAb against PC-12(1),NIH/3T3(2),NRK(3),C2C12(4),C6(5), cell lysate.    


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       Flow cytometric analysis of Hela cells using DKK3 mouse mAb (green) and negative control (red).    


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       Flow cytometric analysis of C6 cells using DKK3 mouse mAb (green) and negative control (red).    


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       Flow cytometric analysis of NIH/3T3 cells using DKK3 mouse mAb (green) and negative control (red).    


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       Flow cytometric analysis of COS7 cells using DKK3 mouse mAb (green) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human brain tissues using DKK3 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded Mouse kidney using DKK3 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded Rat kidney using DKK3 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded Rabbit kidney using DKK3 mouse mAb with DAB staining.    


           

参考文献

以下是关于DKK3抗体的3篇参考文献示例(注:以下内容为示例,具体文献需根据实际研究调整):

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1. **文献名称**: *"DKK3 Neutralizing Antibody Improves Renal Fibrosis by Blocking Wnt/β-Catenin Signaling"*

**作者**: Miao, H., Zhang, Y., & Li, X.

**摘要**: 该研究开发了一种靶向DKK3的中和抗体,并在小鼠慢性肾病模型中验证其疗效。结果显示,抗体治疗显著抑制了肾间质纤维化,机制与阻断Wnt/β-catenin信号通路的异常激活相关,提示DKK3抗体在抗纤维化治疗中的潜力。

2. **文献名称**: *"A Humanized Anti-DKK3 Antibody Enhances Chemotherapy Efficacy in Glioblastoma"*

**作者**: Foroni, C., Rossi, M., & Pellegatta, S.

**摘要**: 研究利用人源化DKK3抗体联合替莫唑胺治疗胶质母细胞瘤。实验表明,抗体通过抑制DKK3介导的肿瘤干细胞信号通路,显著增强化疗药物敏感性,并延长小鼠生存期。

3. **文献名称**: *"Development of a DKK3-Specific ELISA for Early Detection of Hepatocellular Carcinoma"*

**作者**: Wang, L., Chen, T., & Liu, S.

**摘要**: 研究基于DKK3单克隆抗体开发了高灵敏度ELISA检测方法,用于肝癌早期筛查。临床样本分析显示,血清DKK3水平在肝癌患者中显著升高,且与肿瘤分期正相关,验证了其作为新型诊断标志物的价值。

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如需具体文献,建议通过PubMed或Google Scholar检索关键词“DKK3 antibody therapeutic”或“DKK3 biomarker”,并筛选近年研究。

       

背景信息

DKK3 (Dickkopf-related protein 3) is a secreted glycoprotein belonging to the Dickkopf family, known for its role in modulating Wnt signaling pathways. Unlike DKK1 and DKK2. which primarily inhibit canonical Wnt/β-catenin signaling, DKK3 exhibits a more complex regulatory mechanism, interacting with diverse receptors like Kremen and LRP5/6. though its precise molecular targets remain under investigation. It is broadly expressed in adult tissues, including the kidneys, heart, and nervous system, and plays critical roles in embryonic development, tissue homeostasis, and cellular differentiation.

Dysregulation of DKK3 is implicated in multiple pathological conditions. In cancer, DKK3 often acts as a tumor suppressor, with reduced expression observed in malignancies like prostate, lung, and colorectal cancers. Conversely, it may promote fibrosis in chronic kidney disease and cardiac remodeling. DKK3 antibodies, both monoclonal and polyclonal, are vital tools for studying these processes. They enable detection of DKK3 expression via immunohistochemistry, Western blotting, or ELISA, aiding in biomarker research and therapeutic exploration. Recent studies also explore DKK3 antibodies as potential therapeutics to modulate Wnt-related pathways in diseases such as fibrosis or osteoporosis.

Despite progress, challenges persist in understanding context-specific DKK3 functions and optimizing antibody-based interventions. Ongoing research aims to clarify its dual roles in different tissues and diseases, highlighting its therapeutic and diagnostic potential.

       
关键字: DKK3抗体;DKK3;DKK3 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
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