CAMK4抗体,Mouse Monoclonal CAMK4 Antibody
  • CAMK4抗体,Mouse Monoclonal CAMK4 Antibody
  • CAMK4抗体,Mouse Monoclonal CAMK4 Antibody
  • CAMK4抗体,Mouse Monoclonal CAMK4 Antibody

CAMK4抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-10
QQ交谈 微信洽谈

产品详情

中文名称:CAMK4抗体英文名称:Mouse Monoclonal CAMK4 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 571 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Mouse
偶联物: 靶点: CAMK4
2025-05-10 CAMK4抗体 Mouse Monoclonal CAMK4 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 571 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB1/500 - 1/2000 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC1/200 - 1/1000 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesIV; caMK; CaMK IV; CaMK-GR
Entrez GeneID814
clone8C5B8
WB Predicted band size58kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human CAMK4 (AA: 35-292 ) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);    


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       Western blot analysis using CAMK4 mouse mAb against Jurkat (1), SK-N-SH (2), Raji (3), and HeLa (4) cell lysate.    


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       Immunofluorescence analysis of HepG2 cells using CAMK4 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.    


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       Immunohistochemical analysis of paraffin-embedded human ovarian cancer tissues using CAMK4 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human rectum cancer tissues using CAMK4 mouse mAb with DAB staining.    


           

参考文献

以下是关于CAMK4抗体的3篇参考文献示例(注:以下内容为模拟,非真实文献,仅供格式参考):

1. **标题**:*CAMK4 expression in autoimmune diseases: Role of antibody-based detection*

**作者**:Smith A, et al.

**摘要**:研究利用CAMK4抗体分析其在类风湿性关节炎患者外周血单核细胞中的表达,发现CAMK4水平升高与炎症因子IL-17的异常激活相关。

2. **标题**:*CAMK4 regulates T cell differentiation via NFAT signaling: Insights from antibody blockade experiments*

**作者**:Chen L, et al.

**摘要**:通过CAMK4抗体阻断实验,揭示其在T细胞分化中通过调控NFAT入核影响Th17细胞功能,提示其作为潜在免疫治疗靶点。

3. **标题**:*Development of a high-specificity monoclonal CAMK4 antibody for neurodegenerative disease models*

**作者**:Wang Y, et al.

**摘要**:报道一种新型单克隆CAMK4抗体的开发与验证,应用于阿尔茨海默病模型小鼠脑组织检测,发现CAMK4与tau蛋白磷酸化存在关联。

(如需真实文献,建议通过PubMed或Google Scholar检索关键词“CAMK4 antibody”或“CAMK4 function”。)

       

背景信息

The CAMK4 antibody is a crucial tool for studying calcium/calmodulin-dependent protein kinase IV (CAMK4), a serine/threonine kinase involved in calcium-mediated signaling pathways. CAMK4 is expressed in various tissues, including the brain, immune cells, and testes, and plays roles in gene transcription regulation, synaptic plasticity, and immune response modulation. It is activated by calcium/calmodulin binding and phosphorylates downstream targets like CREB (cAMP response element-binding protein), influencing cellular processes such as neuronal differentiation and T-cell activation.

CAMK4 antibodies are widely used in research to detect protein expression, localization, and activity in both normal and pathological conditions. They are essential in studying CAMK4's involvement in diseases like autoimmune disorders, neurodegenerative diseases, and cancer. Common applications include Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Many CAMK4 antibodies are polyclonal or monoclonal, with specificity validated via knockout controls or peptide blocking assays.

Researchers must consider cross-reactivity with related kinases (e.g., CAMK2) and optimize experimental conditions (e.g., fixation methods, buffer compositions) to ensure accuracy. Commercial CAMK4 antibodies often include datasheets detailing epitope regions, host species (e.g., rabbit, mouse), and recommended dilutions. Understanding CAMK4's structural domains (kinase, regulatory, and nuclear localization sequences) aids in selecting antibodies targeting functional regions. Overall, CAMK4 antibodies remain pivotal in elucidating calcium signaling mechanisms and their therapeutic implications.

       
关键字: CAMK4抗体;CAMK4;CAMK4 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
询盘

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