THY1抗体,Mouse Monoclonal THY1 Antibody
  • THY1抗体,Mouse Monoclonal THY1 Antibody
  • THY1抗体,Mouse Monoclonal THY1 Antibody
  • THY1抗体,Mouse Monoclonal THY1 Antibody

THY1抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-10
QQ交谈 微信洽谈

产品详情

中文名称:THY1抗体英文名称:Mouse Monoclonal THY1 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 611 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Mouse
偶联物: 靶点: THY1
2025-05-10 THY1抗体 Mouse Monoclonal THY1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 611 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB1/500 - 1/2000 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC1/200 - 1/1000 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesCD90
Entrez GeneID7070
clone7E1B11
WB Predicted band size18kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Rat
ImmunogenPurified recombinant fragment of human THY1 (AA: 17-132) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);    


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       Western blot analysis using THY1 mouse mAb against T47D (1), HepG2 (2) and PC-12 (3) cell lysate.    


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       Immunofluorescence analysis of Hela cells using THY1 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.    


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       Immunohistochemical analysis of paraffin-embedded human endometrial cancer tissues using THY1 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human cerebellum tissues using THY1 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded Rat spleen using THY1 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded Rat kidney using THY1 mouse mAb with DAB staining.    


           

参考文献

以下是关于THY1抗体的3篇参考文献及其摘要概括:

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1. **文献名称**:*"Thy-1 as a regulator of cell-cell and cell-matrix interactions in pulmonary fibrosis"*

**作者**:Hagood, J.S. et al.

**摘要**:该研究探讨了抗THY1抗体在肺纤维化模型中的作用,发现通过抗体诱导THY1交联可激活成纤维细胞,导致细胞外基质沉积增加,揭示了THY1在调控纤维化信号通路中的关键作用。

2. **文献名称**:*"Thy-1 (CD90) is a novel marker of cancer stem cells in malignant melanoma"*

**作者**:Rege, T.A. & Hagood, J.S.

**摘要**:研究利用抗THY1抗体鉴定黑色素瘤中的癌症干细胞,发现THY1高表达与肿瘤侵袭性和耐药性相关,阻断THY1信号可抑制肿瘤生长,提示其作为治疗靶点的潜力。

3. **文献名称**:*"Thy-1 (CD90) regulates the interaction between melanoma cells and vascular endothelium"*

**作者**:Saalbach, A. et al.

**摘要**:该文献通过抗THY1抗体阻断实验,发现THY1介导黑色素瘤细胞与血管内皮细胞的粘附,影响肿瘤转移过程,揭示了THY1在肿瘤微环境中的调控机制。

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以上研究分别从纤维化、癌症干细胞及肿瘤转移的角度,阐明了THY1抗体的实验应用及其功能机制。

       

背景信息

THY1 antibody targets the THY1 glycoprotein, also known as CD90. a glycosylphosphatidylinositol (GPI)-anchored cell surface protein belonging to the immunoglobulin superfamily. First identified in murine thymocytes in the 1970s, THY1 is evolutionarily conserved and expressed in various cell types, including neurons, fibroblasts, certain stem cells, and activated endothelial cells. Its expression varies across species and tissues; for example, it is abundant in rodent neurons but predominantly found in human fibroblasts. THY1 is implicated in cell adhesion, migration, signaling, and interactions with extracellular matrix components, though its precise biological roles remain under investigation.

In research, THY1 antibodies are widely used as markers to identify and isolate specific cell populations. In neuroscience, they help map neuronal circuits by labeling surface proteins. In immunology and stem cell studies, they assist in characterizing T-cell subsets or mesenchymal stem cells. Function-blocking THY1 antibodies are employed to study its role in processes like fibrosis, cancer metastasis, and immune regulation. Dysregulated THY1 expression has been linked to diseases such as pulmonary fibrosis, glioblastoma, and chronic inflammation, making it a potential therapeutic target. However, species- and tissue-specific expression patterns necessitate careful antibody selection for experimental accuracy.

       
关键字: THY1抗体;THY1;THY1 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
询盘

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