ZEB1抗体,Mouse Monoclonal ZEB1 Antibody
  • ZEB1抗体,Mouse Monoclonal ZEB1 Antibody
  • ZEB1抗体,Mouse Monoclonal ZEB1 Antibody
  • ZEB1抗体,Mouse Monoclonal ZEB1 Antibody

ZEB1抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-10
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产品详情

中文名称:ZEB1抗体英文名称:Mouse Monoclonal ZEB1 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 612 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Mouse
偶联物: 靶点: ZEB1
2025-05-10 ZEB1抗体 Mouse Monoclonal ZEB1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 612 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC1/200 - 1/1000 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesBZP; TCF8; AREB6; FECD6; NIL2A; PPCD3; ZFHEP; ZFHX1A; DELTAEF1
Entrez GeneID6935
clone2A8A6
WB Predicted band size124kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human ZEB1 (AA: 967-1108) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);    


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       Immunofluorescence analysis of Hela cells using ZEB1 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.    


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       Flow cytometric analysis of Hela cells using ZEB1 mouse mAb (green) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human cervical cancer tissues using ZEB1 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human rectum cancer tissues using ZEB1 mouse mAb with DAB staining.    


           

参考文献

以下是3篇关于ZEB1抗体的参考文献及其摘要概括:

1. **"ZEB1: A Critical Regulator of Cell Plasticity and DNA Damage Response"**

- Authors: Zhang P, Sun Y, Ma L

- 摘要:该研究验证了兔源ZEB1抗体(货号AB123)在乳腺癌细胞系中的特异性,通过免疫共沉淀和Western blot证明其能有效识别ZEB1蛋白,并揭示ZEB1通过调控EMT促进化疗耐药。

2. **"Antibody Validation for Epithelial-Mesenchymal Transition Markers"**

- Authors: Vandewalle C, Van Roy F

- 摘要:系统性评估多种EMT相关抗体,包括小鼠单克隆ZEB1抗体(Clone 3F10)。通过免疫荧光和流式细胞术确认其在结肠癌细胞中的特异性,发现ZEB1高表达与转移相关。

3. **"ZEB1 Antibody Application in Pancreatic Cancer Studies"**

- Authors: Singh A, Settleman J

- 摘要:使用兔多克隆ZEB1抗体(货号HPA027524)分析胰腺癌组织芯片,发现ZEB1在肿瘤基质中的表达与患者预后负相关,抗体经肽段竞争实验验证特异性。

注:以上为虚构示例,实际文献需通过PubMed/Google Scholar检索关键词"ZEB1 antibody validation"获取,推荐关注《Nature Communications》《Cell Reports》等期刊近年研究。

       

背景信息

ZEB1 (zinc finger E-box-binding homeobox 1) is a transcription factor belonging to the Zinc finger E-box binding (ZEB) protein family, known for its critical role in epithelial-mesenchymal transition (EMT). EMT is a biological process involved in embryonic development, wound healing, and cancer metastasis, where epithelial cells lose adhesion and gain migratory properties. ZEB1 suppresses epithelial markers (e.g., E-cadherin) and promotes mesenchymal markers (e.g., vimentin), facilitating cell invasion and metastasis in cancers like breast, lung, and colorectal carcinomas.

ZEB1 antibodies are essential tools for detecting and quantifying ZEB1 protein expression in research. They are widely used in techniques such as Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and flow cytometry. These antibodies are typically raised against specific epitopes of human ZEB1. with common host species including rabbit, mouse, and goat. Both monoclonal and polyclonal variants are available, each offering distinct advantages: monoclonal antibodies provide high specificity, while polyclonal antibodies may enhance sensitivity for detecting low-abundance targets.

Validation of ZEB1 antibodies is crucial, as cross-reactivity with homologous proteins (e.g., ZEB2) or non-specific binding can affect data reliability. Researchers often use knockout cell lines or siRNA-mediated ZEB1 knockdown to confirm antibody specificity. In cancer research, ZEB1 expression is studied to assess EMT progression, tumor aggressiveness, and therapeutic resistance. Commercial ZEB1 antibodies are often accompanied by validation data from peer-reviewed studies, ensuring reproducibility across experimental models.

       
关键字: ZEB1抗体;ZEB1;ZEB1 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
普通会员
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
询盘

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