The PAPLN (papilin) antibody is a tool used to detect papilin, an extracellular matrix (ECM) glycoprotein involved in tissue development and remodeling. Papilin, encoded by the *PAPLN* gene in humans, belongs to the ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) family-binding protein subgroup. It contains multiple thrombospondin type 1 repeats (TSRs) and a conserved protease inhibitor-like domain, suggesting roles in modulating cell-ECM interactions and protease activity. Studies indicate papilin influences basement membrane structure, cell adhesion, and morphogenesis during embryogenesis. In disease contexts, altered PAPLN expression has been linked to cancer progression, fibrosis, and connective tissue disorders, though its precise mechanisms remain under investigation. The PAPLN antibody is widely utilized in immunoassays (e.g., Western blot, immunohistochemistry) to study protein localization, expression levels, and functional pathways in developmental biology and disease models. Its specificity varies depending on the epitope targeted, with some antibodies recognizing conserved regions across species (e.g., human, mouse). Research using PAPLN antibodies continues to clarify its regulatory roles in ECM dynamics and potential therapeutic applications.